Dr. Stephanie Lee and her staff are located at Fred Hutchinson Cancer Research Center. Our work focuses on hematopoietic stem cell transplant patients and chronic graft-versus-host disease (cGHVD). Dr. Lee is the lead investigator and Fred Hutchinson Cancer Research Center is the coordinating center for the Chronic Graft-versus-Host Disease Consortium within the Rare Diseases Clinical Research Network.
More information about the cGVHD Consortium can be found here: http://rarediseasesnetwork.epi.usf.edu/cGVHD/index.htm
Recipients of allogeneic hematpoietic cell transplants (HCT) suffer from unique immune mediated disorders. Although components of these disorders resemble known autoimmune syndromes or solid organ allograft rejections, the underlying immunology is poorly characterized. In 2007, approximately 9,500 allogeneic HCTs were performed in the United States, primarily for the treatment of rare diseases such as leukemia, lymphoma, multiple myeloma and other hematologic diseases. Approximately 50% of allogeneic HCT recipients develop immune mediated disorders resulting in high treatment-related morbidity and mortality. The two most common immune mediated complications are heterogeneous syndromes collectively called "acute graft-versus-host disease (GVHD)" and "chronic GVHD". Chronic GVHD is the leading cause of non-relapse death more than 2 years after allogeneic HCT. The different syndromes within GVHD are likely to have different pathogenic mechanisms. The goal of Dr. Lee and colleagues is to advance our understanding and treatment of these disorders.
Dr. Lee's expertise and interest focuses on survivorship issues, quality-of-life issues and the impact of GVHD. Other areas of interest include health-services research, which includes analysis of physician practices, cost-effectiveness analysis and similar policy issues. Dr. Lee also enjoys examining the psychosocial predictors of outcomes; does depression change how people do in transplants? Does optimism improve someone's chances of getting through a transplant?