Trask Lab
Publications
Publications
Recent publications
Young JM, Kambere M, Trask BJ, Lane RP. Divergent V1R repertoires in five species: Amplification in rodents, decimation in primates, and a surprisingly small repertoire in dogs.Genome Res. 2005 15(2):231-240. AbstractLoo LW, Grove DI, Williams EM, Neal CL, Cousens LA, Schubert EL, Holcomb IN, Massa HF, Glogovac J, Li CI, Malone KE, Daling JR, Delrow JJ, Trask BJ, Hsu L, Porter PL. Array comparative genomic hybridization analysis of genomic alterations in breast cancer subtypes. Cancer Res. 2004 64(23):8541-8549. Abstract
Lane RP, Young J, Newman T, Trask BJ. Species specificity in rodent pheromone receptor repertoires. Genome Res. 2004 14(4):603-8. Abstract
Gibbs RA et al. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 2004 428(6982):493-521. Abstract
Young JM, Shykind BM, Lane RP, Tonnes-Priddy L, Ross JA, Walker M, Williams EM, Trask BJ. Odorant receptor expressed sequence tags demonstrate olfactory expression of over 400 genes, extensive alternate splicing and unequal expression levels.Genome Biol. 2003 4(11):R71 Abstract
Newman T, Trask BJ. Complex evolution of 7E olfactory receptor genes in segmental duplications.Genome Res. 2003 13(5):781-93 Abstract
Fan Y, Newman T, Linardopoulou E, Trask BJ. Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions. Genome Res. 2002 12(11):1663-72. Abstract
Fan Y, Linardopoulou E, Friedman C, Williams E, Trask BJ. Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes. Genome Res. 2002 12(11):1651-62. Abstract
Trask, BJ. Human Genetics and Disease: Human cytogenetics: 46 chromosomes, 46 years and counting. Nature Reviews Genetics 2002 3:769-778. Abstract PDF
Gygi MP, Ferguson MD, Mefford HC, Lund KP, O'Day C, Zhou P, Friedman C, van den Engh G, Stolowitz ML, Trask BJ. Use of fluorescent sequence-specific polyamides to discriminate human chromosomes by microscopy and flow cytometry. Nucleic Acids Res. 2002 30(13):2790-9. Abstract
Tanaka H, Tapscott SJ, Trask BJ, Yao MC. Short inverted repeats initiate gene amplification through the formation of a large DNA palindrome in mammalian cells. PNAS. 2002 99(13):8772-7. Abstract
Young JM, Trask BJ. The sense of smell: genomics of vertebrate odorant receptors.Hum Mol Genet. 2002 11(10):1153-60. Abstract
Young JM, Friedman, C, Williams, EM, Ross, JA, Tonnes-Priddy, L, Trask, BJ. Different evolutionary processes shaped the mouse and human olfactory receptor gene families. Hum Mol Genet. 2002 11(5):535-546. Abstract
Mefford, HC and Trask, BJ. The complex structure and dynamic evolution of human subtelomeres. Nature Reviews Genetics 2002 3, 91-102. Abstract PDF
Lane RP, Roach JC, Lee IY, Boysen C, Smit A, Trask BJ, Hood L. Genomic Analysis of the Olfactory Receptor Region of the Mouse and Human T-Cell Receptor alpha/delta Loci. Genome Res. 2002 12(1):81-7. Abstract
Lane RP, Cutforth T, Axel R, Hood L, Trask BJ. Sequence analysis of mouse vomeronasal receptor gene clusters reveals common promoter motifs and a history of recent expansion. PNAS 2002 99(1):291-6. Abstract
Linardopoulou E, Mefford HC, Nguyen O, Friedman C, van den Engh G, Farwell DG, Coltrera M, Trask BJ. Transcriptional activity of multiple copies of a subtelomerically located olfactory receptor gene that is polymorphic in number and location. Hum MolGenet. 2001 10(21):2373-83. Abstract
Mefford HC, Linardopoulou E, Coil D, van den Engh G, Trask BJ. Comparative sequencing of a multicopy subtelomeric region containing olfactory receptor genes reveals multiple interactions between non-homologous chromosomes. Hum Mol Genet. 2001 10(21):2363-72. Abstract
Lane, R.P., Cutforth, T., Young J., Athanasiou, M., Friedman, C., Rowen, L., Evans, G., Axel, R., Hood, L., Trask, B.J. Genomic analysis of orthologous mouse and human olfactory receptor loci indicates partial cluster stability yet minimal conservation beyond the coding sequence. PNAS. 2001 98: 7390-7395. Abstract
The BAC Resource Consortium (60 authors, corresponding author B.J. Trask). Integration of cytogenetic landmarks into the draft sequence of the human genome. Nature. 2001 409:953-958. Abstract
The International Human Genome Mapping Consortium (113 authors, corresponding author J.D. McPherson). A physical map of the human genome. Science. 2001 409:934-941. Abstract
Olivier, M. et al. (55 authors). A high-resolution radiation hybrid map of the human genome draft sequence. Science. 2001 291:1298-1302. Abstract
Bailey, J.A., Yavor, A.M., Massa, H., Trask, B.J., Eichler, E.E.. Segmental duplications: organization and impact within the current Human Genome Project assembly. Genome Res. 2001 11: 1-13.Abstract
Giorgi D, Friedman C, Trask BJ, Rouquier S. Characterization of nonfunctional V1R-like pheromone receptor sequences in human. Genome Res. 2000 10(12): 1979-85.
Sachs RK, Hlatky LR, Trask BJ. Radiation-produced chromosome aberrations: colourful clues. Trends in Genetics. 2000 16(4):143-6.
Deng Y, Madan A, Banta AB, Friedman C, Trask BJ, Hood L, Li L. Characterization, chromosomal localization, and the complete 30-kb DNA sequence of the human Jagged2 (JAG2) gene. Genomics. 2000 63(1):133-8.
Lin B, White JT, Ferguson C, Bumgarner R, Friedman C, Trask B, Ellis W, Lange P, Hood L, Nelson PS. PART-1: A novel human prostate-specific, androgen-regulated gene that maps to chromosome 5q12. Cancer Research. 2000 60:858-860.
Singer MJ, Mesner LD, Friedman C, Trask BJ, Hamlin JL. Amplification of the human dihydrofolate reductase gene via double minutes is initiated by chromosome breaks. PNAS. 2000 97:7921-7926.
Siegel AF, van den Engh G, Hood L, Trask BJ, Roach J. Modeling the feasibility of whole genome shotgun sequencing using a pairwise end strategy. Genomics. 2000 68: 247-252.
Yokota H, Fung K, Trask BJ, van den Engh G, Sarikaya M, Aebersold R. Sharp DNA bends as landmarks of protein-binding sites on straightened DNA. Anal Chem. 1999 71(9):1663-7.
DeSilva U, Massa H, Trask BJ, Green ED. Comparative mapping of the region of human chromosome 7 deleted in williams syndrome. Genome Res. 1999 9(5):428-36.
Brand-Arpon V, Rouquier S, Massa H, de Jong PJ, Ferraz C, Ioannou PA, Demaille JG, Trask BJ, Giorgi D. A genomic region encompassing a cluster of olfactory receptor genes and a myosin light chain kinase (MYLK) gene is duplicated on human chromosome regions 3q13-q21 and 3p13. Genomics. 1999 56(1):98-110.
Katz SG, Schneider SS, Bartuski A, Trask BJ, Massa H, Overhauser J, Lalande M, Lansdorp PM, Silverman GA. An 18q- syndrome breakpoint resides between the duplicated serpins SCCA1 and SCCA2 and arises via a cryptic rearrangement with satellite III DNA.. Hum Mol Genet. 1999 8(1):87-92.
Siegel AF, Trask BJ, Roach J, Mahairas GG, Hood L, van den Engh G. Analysis of Sequence-Tagged Conector (STC) strategies for DNA sequencing. Genomics. 1999 9:297-307.
Vissinga CS, Yeo TC, Woessner J, Massa HF, Wilson RK, Trask BJ, Concannon P. Identification and characterization of a mouse homologue of the gene mutated in Nijmegen breakage. Cytogenetics and Cell Genetics. 1999 87:80-84.
Roach JC, Siegel AF, van den Engh G, Trask BJ, Hood L. Gaps in the human genome project. Nature. 401: 843-845, 1999
Bartuski AJ, Kamachi Y, Schick C, Massa H, Trask BJ, Silverman GA. A murine ortholog of the human serpin SCCA2 maps to chromosome 1 and inhibits chymotrypsin-like serine proteinases. Genomics. 1998 54(2):297-306.
Trask BJ, Massa H, Brand-Arpon V, Chan K, Friedman C, Nguyen OT, Eichler E, van den Engh G, Rouquier S, Shizuya H, Giorgi D. Large multi-chromosomal duplications encompass many members of the olfactory receptor gene family in the human genome. Hum Mol Genet. 1998 7(13):2007-20
Yokota H, Nickerson DA, Trask BJ, van den Engh G, Hirst M, Sadowski I, Aebersold R. Mapping a protein-binding site on straightened DNA by atomic force microscopy. Anal Biochem. 1998 264(2):158-64.
Meng X, Lu X, Li Z, Green ED, Massa H, Trask BJ, Morris CA, Keating MT. Complete physical map of the common deletion region in Williams syndrome and identification and characterization of three novel genes. Hum Genet. 1998 103(5):590-9.
Rouquier S, Friedman C, Delettre C, van den Engh G, Blancher A, Crouau-Roy B, Trask B J, Giorgi D. A gene recently inactivated in uman defines a new olfactory receptor family in mammals.. Human Molecular Genetics. 7(9): 1337-45, Sep 1998
Li L, Huang G M, Banta A B, Deng Y, Smith T, Dong P, Friedman C, Chen L, Trask B J, Spies T, Rowen L, Hood L. Cloning, characterization, and the complete 56.8-kilobase DNA sequence of the human NOTCH4 gene. Genomics. 1998 51(1):45-58.
Chaudhary P M, Ferguson C, Nguyen V, Nguyen O, Massa H F, Eby M, Jasmin A, Trask B J, Hood L, Nelson P S. Cloning and characterization of two Toll/Interleukin-1 receptor-like genes TIL3 and TIL4: evidence for a multi-gene receptor family in humans. Blood. 1998 91(11): 4020-7.
La Spada A R, Peterson K R, Meadows S A, McClain M E, Jeng G, Chmelar R S, Haugen H A, Chen K, Singer M J, Moore D, Trask B J, Fischbeck K H, Clegg C H, McKnight G S. Androgen receptor YAC transgenic mice carrying CAG 45 alleles show trinucleotide repeat instability. Hum Mol Genet. 1998 7(6):959-67.
Rouquier S, Taviaux S, Trask B J, Brand-Arpon V, van den Engh G, Demaille J, Giorgi D. Distribution of olfactory receptor genes in the human genome. Nature Genetics. 1998 18(3):243-50.
Thai T H, Du F, Tsan J T, Jin Y, Phung A, Spillman M A, Massa H F, Muller C Y, Ashfaq R, Mathis J M, Miller D S, Trask B J, Baer R, Bowcock A M. Mutations in the BRCA1-associated RING domain (BARD1) gene in primary breast, ovarian and uterine cancers. Hum Mol Genet. 1998 7(2):195-202.
Sharma V, Poorkaj P, Hisama F, Bonnycastle L, Yu C E, Massa H, Trask B, Clancy K P, Patterson D, Weissman S M, Schellenberg G D. An expression map from human chromosome 14q24.3. Genomics. 1998 47(2):314-8.
Li L, Milner L A, Deng Y, Iwata M, Banta A, Graf L, Marcovina S, Friedman C, Trask B J, Hood L, Torok-Storb B. The human homolog of rat Jagged1 expressed by marrow stroma inhibits differentiation of 32D cells through interaction with Notch1. Immunity. 1998 8(1):43-55.
Trask B J, Friedman C, Martin-Gallardo A, Rowen L, Akinbami C, Blankenship J, Collins C, Giorgi D, Iadonato S, Johnson F, Kuo W L, Massa H, Morrish T, Naylor S, Nguyen O T, Rouquier S, Smith T, Wong D J, Youngblom J, van den Engh G. Members of the olfactory receptor gene family are contained in large blocks of DNA duplicated polymorphically near the ends of human chromosomes. Hum Mol Genet. 1998 7(1):13-26.
Han D K, Chaudhary P M, Wright M E, Friedman C, Trask B J, Riedel R T, Baskin D G, Schwartz S M, Hood L. MRIT, a novel death-effector domain-containing protein, interacts with caspases and BclXL and initiates cell death. PNAS 1997 94(21):11333-8.
Mefford H, van den Engh G, Friedman C, Trask B J. Analysis of the variation in chromosome size among diverse human populations by bivariate flow karyotyping. Human Genetics. 1997 100(1):138-44.
Li L, Krantz I D, Deng Y, Genin A, Banta A B, Collins C C, Qi M, Trask B J, Kuo W L, Cochran J, Costa T, Pierpont M E, Rand E B, Piccoli D A, Hood L, Spinner N B. Alagille syndrome is caused by mutations in human Jagged1, which encodes a ligand for Notch1. Nature Genetics. 1997 16(3):243-51.
Yokota H, Singer M J, van den Engh G J, Trask B J. Regional differences in the compaction of chromatin in human G0/G1 interphase nuclei. Chromosome Research. 1997 5(3):157-66.
Geier S J, Algate P A, Carlberg K, Flowers D, Friedman C, Trask B, Rohrschneider L R. The human SHIP gene is differentially expressed in cell lineages of the bone marrow and blood. Blood. 1997 89(6):1876-85.
Yokota H, Johnson F, Lu H, Robinson R M, Belu A M, Garrison M D, Ratner B D, Trask B J, Miller D L. A new method for straightening DNA molecules for optical restriction mapping. Nucleic Acids Research. 1997 25(5):1064-70.
Lanyi A, Li B, Li S, Talmadge C B, Brichacek B, Davis J R, Kozel B A, Trask B, van den Engh G, Uzvolgyi E, Stanbridge E J, Nelson D L, Chinault C, Heslop H, Gross T G, Seemayer T A, Klein G, Purtilo D T, Sumegi J. A yeast artificial chromosome (YAC) contig encompassing the critical region of the X-linked lymphoproliferative disease (XLP) locus. Genomics. 1997 39(1):55-65.
Trask B J, Mefford H, van den Engh G, Massa H F, Juyal R C, Potocki L, Finucane B, Abuelo D N, Witt D R, Magenis E, Baldini A, Greenberg F, Lupski J R, Patel P I. Quantification by flow cytometry of chromosome-17 deletions in Smith-Magenis syndrome patients. Human Genetics. 1996 98(6):710-8.
Gorski J L, Bialecki M D, McDonald M T, Massa H F, Trask B J, Burright E N. Cosmids map two incontinentia pigmenti type 1 (IP1) translocation breakpoints to a 180-kb region within a 1.2-Mb YAC contig. Genomics. 1996 35(2):338-45.
Liao X, Ma C, Trask B, Massa H, Gilbert D J, Staudt L M, Jenkins N A, Copeland N G. LAF4 maps to mouse chromosome 1 and human chromosome 2q11.2-q12. Mammalian Genome. 1996 7(6):467-8.
Ignatius J, Knuutila S, Scherer S W, Trask B, Kere J. Split hand/split foot malformation, deafness, and mental retardation with a complex cytogenetic rearrangement involving 7q21.3. Journal of Medical Genetics. 1996 33(6):507-10.
