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Ray Monnat, Jr.
Departments of Pathology and Genome Sciences University of Washington

Molecular Biology of Double Strand Breaks; Homing Endonucleases
Flick, K.E., Jurica, M. S., Monnat, R. J. Jr., and Stoddard, B. L. (1998) "DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI" Nature 394: 96 - 101.
Jurica, M. S., Monnat, R. J. Jr. and Stoddard, B. L. (1998) "DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI" Molecular Cell 2: 469 - 476. |
Andy Scharenberg
Department of Pediatrics University of Washington School of Medicine and Children's Hospital

Molecular Biology of Ions Channels;
Gene Therapy and SCID disorders
Shen, B. W., Perraud, A. -L., Scharenberg, A. M. and Stoddard, B. L. (2003) "The crystal structure and mutational analysis of human NUDT9" J. Mol. Biol. 332(2):385-98. |
David Baker
Departments of Biochemistry and Bioengineering University of Washington

Protein Structure Prediction and Engineering
Kuhlman, B., Dantas, G., Ireton, G., Varani, G., Stoddard, B. L. and Baker, D. (2004) "Design of a novel protein fold with atomic accuracy" Science 302: 1364 - 1368.
Korkegian, A., Baker, D. and Stoddard, B. L. (2005) "Computational thermostabilization of an enzyme catalyst" Science 308: 857 - 860 |
Margaret Black
Department of Pharmaceutical Sciences Washington State University

Directed Evolution of Enzymes and Anti-tumor Gene Therapy
Ireton, G., McDermitt, G., Black, M. and Stoddard, B. L. (2002) "The structure of Escherichia coli cytosine deaminase" J. Mol. Biol. 315(4): 687 - 697.
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Monique Turmel and Claude Lemieux
Centre de recherche sur la Fonction, la structure et l'Ingenierie des Proteines Universite Laval, Quebec City

Evolution and molecular biology of mobile introns and homing endonucleases
Chevalier, B., Turmel, M., Lemieux, C., Monnat, R. J. Jr. and Stoddard, B. L. (2003) "Flexible DNA target site recognition by divergent homing endonuclease isoschizomers I-CreI and I-MsoI" J. Mol. Biol. 329: 253 - 269.
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Jim Samuelson, Geoff Wilson, John Pelletier, et al.
New England Biolabs Ipswich, MA

Molecular Biology of Restriction Endonucleases, Polymerases and Kinase/Phosphatases
Galburt, E., Pelletier, J., Wilson G., and Stoddard, B. L. (2002) "Structure of a tRNA repair enzyme and molecular biology workhorse, T4 polynucleotide kinase" Structure 10 (9): 1249 - 1260.
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Mark Caprara
Center for RNA Microbiology Case Western University, Cleveland OH

Molecular Biology of RNA splicing and Maturase cofactors
Bolduc, J. M., et al. and, Caprara, M. G., Waring, R. B. and Stoddard, B. L. (2003) "Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor" Genes and Development 17: 2875-2888.
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David Shub
Departments of Pathology and Genome Sciences State University of New York in Albany

Molecular Biology of mobile introns and homing endonucleases
Shen, B. W., Landthaler, M., Shub, D. A. and Stoddard, B. L. (2004) "DNA binding and cleavage by the HNH homing endonuclease I-HmuI" J. Mol. Biol. 342 (1): 34 - 56.
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Andy Mesecar
Departments of Pathology and Genome Sciences University of Illinois in Chicago

Structural enzymology and engineering
Jurica, M. S., Heath, P. J., Shi, W., Mesecar, A., and Stoddard, B. L. (1998) "The allosteric regulation of pyruvate kinase by fructose-1,6-bis-phosphate" Structure 6 (2): 195 - 210.
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Len Seligman
Departments of Biology Pomona College

Selection and engineering of homing endonucleases
Sussman, D., Chadsey, M., Fauce, S., Engel, A., Bruett, A., Monnat, R. J. Jr., Stoddard, B. L. and Seligman, L. (2004) "Isolation and characterization of new homing endonuclease specificities at individual target site positions" J. Mol. Biol. 342 (1): 31 - 41.
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Nina Salama
Human Biology Research Division Fred Hutchinson Cancer Center

Structural genomic analyses of Helicobacter pylori
What? No papers yet?!!??
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Julian Simon
Clinical and Human Biology Research Divisions Fred Hutchinson Cancer Center

Chemical biology and compound screening against validated drug targets
Spiegel, P.C., Kaiser, S. M., Simon, J. and Stoddard, B. L. (2004) "Disruption of protein-membrane binding and identification of small molecule inhibitors of coagulation factor VIII" Chemistry and Biology 11 (10): 1413 - 1422.
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