The Stoddard Lab Collaborators

Below are our collaborators, and examples of joint publications. 
Click on their pictures to go to their lab home pages or departmental pages.


Ray Monnat, Jr.

Departments of Pathology and Genome Sciences
University of Washington




Molecular Biology of Double Strand Breaks;
Homing Endonucleases

Flick, K.E., Jurica, M. S., Monnat, R. J. Jr.,  and Stoddard, B. L. (1998) "DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI" Nature 394: 96 - 101.

Jurica, M. S., Monnat, R. J. Jr. and Stoddard, B. L. (1998) "DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI" Molecular

Cell 2: 469 - 476.

Andy Scharenberg

Department of Pediatrics
University of Washington School
of Medicine and Children's Hospital



Molecular Biology of Ions Channels;
Gene Therapy and SCID disorders

Shen, B. W., Perraud, A. -L., Scharenberg, A. M.  and Stoddard, B. L. (2003) "The crystal structure and mutational analysis of human  NUDT9"  J. Mol. Biol. 332(2):385-98.


David Baker

      Departments of Biochemistry and Bioengineering       
University of Washington




Protein Structure Prediction and Engineering


Kuhlman, B., Dantas, G., Ireton, G., Varani, G.,  Stoddard, B. L. and Baker, D. (2004) "Design of a novel protein fold with atomic accuracy" Science 302: 1364 - 1368.

Korkegian, A., Baker, D. and Stoddard, B. L. (2005) "Computational thermostabilization of an enzyme catalyst" Science 308: 857 - 860


Margaret Black

Department of  Pharmaceutical Sciences
Washington State University 




Directed Evolution of Enzymes and Anti-tumor
Gene Therapy


Ireton, G., McDermitt, G., Black, M. and Stoddard, B. L. (2002) "The structure of Escherichia coli cytosine deaminase" J. Mol. Biol. 315(4): 687 - 697.


Monique Turmel and Claude Lemieux

Centre de recherche sur la Fonction, la structure et l'Ingenierie des Proteines
Universite Laval, Quebec City



Evolution and molecular biology
of mobile introns and homing endonucleases


Chevalier, B., Turmel, M., Lemieux, C., Monnat, R. J. Jr. and Stoddard, B. L. (2003) "Flexible DNA target site recognition by divergent homing endonuclease
isoschizomers I-CreI and I-MsoI" J. Mol. Biol. 329: 253 - 269. 



Jim Samuelson, Geoff Wilson, John Pelletier, et al.

New England Biolabs
Ipswich, MA




Molecular Biology of Restriction Endonucleases,
Polymerases and Kinase/Phosphatases


Galburt, E., Pelletier, J., Wilson G., and Stoddard, B. L. (2002) "Structure of a tRNA repair enzyme and molecular biology workhorse, T4 polynucleotide kinase" Structure 10 (9): 1249 - 1260.

Mark Caprara

Center for RNA Microbiology
Case Western University, Cleveland OH



Molecular Biology of RNA splicing
and Maturase cofactors



Bolduc, J. M., et al. and, Caprara, M. G., Waring, R. B. and Stoddard, B. L. (2003) "Structural and biochemical analyses of DNA and RNA binding by a bifunctional homing endonuclease and group I intron splicing factor" Genes and Development 17: 2875-2888.


David Shub

Departments of Pathology and Genome Sciences
State University of New York in Albany



Molecular Biology of mobile introns
and homing endonucleases


Shen, B. W., Landthaler, M., Shub, D. A. and Stoddard, B. L.  (2004) "DNA binding and cleavage by the HNH homing endonuclease I-HmuI"  J. Mol. Biol. 342 (1): 34 - 56.

Andy Mesecar

Departments of Pathology and Genome Sciences
University of Illinois in Chicago



Structural enzymology and engineering



Jurica, M. S., Heath, P. J., Shi, W., Mesecar, A., and Stoddard, B. L. (1998) "The allosteric regulation of pyruvate kinase by fructose-1,6-bis-phosphate" Structure 6 (2): 195 - 210.

Len Seligman

Departments of Biology
Pomona College



Selection and engineering of homing endonucleases



Sussman, D., Chadsey, M., Fauce, S., Engel, A., Bruett, A., Monnat, R. J. Jr., Stoddard, B. L. and Seligman, L. (2004) "Isolation and characterization of new homing endonuclease specificities at individual target site positions" J. Mol. Biol. 342 (1): 31 - 41.

Nina Salama

Human Biology Research Division
Fred Hutchinson Cancer Center



Structural genomic analyses of
Helicobacter pylori



What?  No papers yet?!!??


Julian Simon

Clinical and Human Biology Research Divisions
Fred Hutchinson Cancer Center



Chemical biology and compound
screening against validated drug targets



Spiegel, P.C., Kaiser, S. M., Simon, J. and Stoddard, B. L. (2004) "Disruption of protein-membrane binding and identification of small molecule inhibitors of coagulation factor VIII" Chemistry and Biology 11 (10): 1413 - 1422.



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