SELECTED PUBLICATIONS

Dai Z., Turtle C.J., Booth G.C., Ridell S.R., Gooley T.A., Stevens A.M., Spies T. & Groh V. Normally occurring NKG2D⁺CD4⁺ T cells are immunosuppressive and inversely correlated with disease activity in juvenile-onset lupus. J. Exp. Med. 206, 793-805 (2009). Full text PDF

Spies T. Regulation of NKG2D ligands: a purposeful but delicate affair. Nat. Immunol. 9, 1013-1015 (2008).

Kaiser B.K., Yim D., Chow I.-T., Gonzalez, S., Dai Z., Mann H.H., Strong R., Groh V. & Spies T. Disulfide isomerase-enabled shedding of tumour-associated NKG2D ligands. Nature 447, 482-486 (2007). Full text PDF

Venkataraman G.M., Suciu D., Groh V., Boss J.M. & Spies T. Promoter region architecture and transcriptional regulation of the genes for the MHC class I-related chain A and B ligands of NKG2D. J. Immunol. 178, 961-969 (2007). Full text PDF

Groh V., Smythe K., Dai Z. & Spies T. Fas ligand-mediated paracrine T cell regulation by NKG2D in tumor immunity. Nat. Immunol. 7, 755-762 (2006). Full text PDF

Gonzales S., Groh V. & Spies T. Immunobiology of human NKG2D and its ligands. Curr. Topics Microbiol. Immunol. 298, 121-138 (2006). Full text PDF

Groh V., Li Y.Q., Cioca D., Hunder N.N., Wang W., Riddell S.R., Yee C. & Spies T. Efficient cross-priming of antigen-specific T cells by dendritic cells sensitized with diverse anti-MICA opsonized tumor cells. Proc. Natl. Acad. Sci. USA 102, 6461-6466 (2005). Full text PDF

Groh V., Brühl A., Nelson J.L., El-Gabalawi H. & Spies T. Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc. Natl. Acad. Sci. USA 100, 9452-9457 (2003). Full text PDF

Wu J., Chalupny N.J., Manley T.J., Riddell S.R., Cosman D. & Spies T. Intracellular retention of the MHC class I-related chain B ligand of NKG2D by the human CMV UL16 glycoprotein. J. Immunol. 170, 4196-4200 (2003). Full text PDF

Groh V., Wu J., Yee C. & Spies T. Tumour-derived soluble MIC ligands impair expression of NKG2D and T-cell activation. Nature 419, 734-738 (2002). Full text PDF

Wu J., Groh V. & Spies T. T cell antigen receptor engagement and specificity in the recognition of stress-inducible MIC by human epithelial γδ T cells. J. Immumol. 169, 1236-1240 (2002).

Li P., Morris D.L., Willcox B.E., Steinle A., Spies T. & Strong R.K. Complex structure of the activating immunoreceptor NKG2D and its MHC class I-like ligand MICA. Nat. Immunol. 2, 443-451 (2001). Full text PDF

Groh V., Rhinehart R., Randolph-Habecker J., Topp M.S., Riddell S.R. & Spies T. Potent costimulation of CD8 αβ T-cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat. Immunol. 2, 255-260 (2001). Full text PDF

Wu J., Song Y., Bakker A.B.H., Bauer S., Spies T., Lanier L.L. & Phillips J.H. An activating immunoreceptor complex formed by NKG2D and DAP10. Science 285, 730-732 (1999).

Bauer S., Groh V., Wu J., Steinle A., Phillips J.H., Lanier L.L. & Spies T. Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science 285, 727-729 (1999). Full text PDF

Groh V., Rhinehart R., Secrist H., Bauer S., Grabstein K.H. & Spies T. Broad tumor-associated expression and recognition by tumor-derived γδ T cells of MICA and MICB. Proc. Natl. Acad. Sci. USA 96, 6879-6884 (1999).

Groh V., Steinle A., Bauer S. & Spies T. Recognition of stress-induced MHC molecules by intestinal epithelial γδ T cells. Science 279, 1737-1740 (1998). Full text PDF