Simon Lab at the FHCRC
These data have not been endorsed by the National Cancer Institute or the Fred Hutchinson Cancer Research Center.
The details of how the yeast screen was carried out. A detailed bar graph for each drug against the panel of 22 strains can be obtained from the Simon Lab home page.
This is a graphical summary of the results obtained for 22 FDA-approved anticancer drugs in the yeast screen. The drugs are grouped by mechanism of action with the alkylating agents followed by antimetabolites, Actinomycin D, topoisomerase II poisons, a Camptothecin derivative (topoisomerase I poison) and Bleomycin, a DNA cutter. The color code indicates the difference in sensitivity of a mutant strain versus that of the wild type strain. Blue indicates less than 0.2 log units (mutant IC50 less than 1.6 times wild type IC50) difference; green -- more than 0.2 log units (1.6 times) difference; yellow -- more than 0.5 log units (3.16 times) difference; orange -- more than 1 log unit (10 times) difference, and red -- more than 1.5 log units (31.6 times) difference.
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