Published Articles

2008

Control of the reversibility of cellular quiescence by the transcriptional repressor HES1.
Science, vol. 321(5892): 1095-1100, 2008.
Sang, L., Coller, H.A., and Roberts, J.M.

Cyclin E phosphorylation regulates cell proliferation in hematopoietic and epithelial lineages in vivo.
Genes Dev., vol. 22(12): 1677-1689, 2008.
Minella, A.C., Loeb, K.R., Knecht, A., Welcker, M., Varnum-Finney, B.J., Bernstein, I.D., Roberts, J.M., and Clurman, B.E.

CDK inhibitors: cell cycle regulators and beyond.
Dev. Cell., vol. 14(2): 159-169, 2008.
Besson, A., Dowdy, S.F., and Roberts, J.M.

2007

p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Bull. Mem. Acad. R. Med. Belg., vol. 162(5-6): 310-314, 2007.
[Article in French]
Nguyen, L., Besson, A., Heng, J.I., Schuurmans, C., Teboul, L., Parras, C., Philpott, A., Roberts, J.M. and Guillemot, F..

Discovery of an oncogenic activity in p27Kip1 that causes stem cell expansion and a multiple tumor phenotype.
Genes Dev., vol. 21: 1731-1746, 2007.
Besson, A., Hwang, H.C., Donovan, S.L., Cicero S., Gurian-West, M., Johnson, D., Clurman, B.E., Dyer, M.A., and Roberts, J.M. 

A mechanism misregulating p27 in tumors discovered in a functional genomic screen.
PLOS Genetics, vol. 3(12): 1-13, 2007.
Garrett-Engele, C.M., Tasch, M.A., Hwang, H.C., Fero, M.L., Perlmutter, R.M., Clurman, B.E., and Roberts, J.M. 

A Skp2 autoinduction loop and restriction point control.
J. Cell Biol., vol. 178(5): 741-747, 2007.
Yung, Y., Walker, J.L., Roberts, J.M., and Assoian, R.K.

Kinase-independent function of cyclin E.
Mol. Cell, vol. 25(1): 127-139, 2007.
Geng, Y., Lee, Y.M., Welcker, M., Swanger, J., Zagozdon, A., Winer, J.D., Roberts, J.M., Kaldis, P., Clurman, B.E., and Sicinski, P.

Ubiquitin-independent degradation of cell-cycle inhibitors by the REGgamma proteasome.
Mol. Cell, vol. 26(6): 843-852, 2007.
Chen, X., Barton, L.F., Chi, Y., Clurman, B.E., and Roberts, J.M.

2006

Testing the importance of p27 degradation by the SCFskp2 pathway in murine models of lung and colon cancer.
Proc. Natl. Acad. Sci. USA, vol. 103(38): 14009-14014, 2006.
Timmerbeul, I., Garrett-Engele, C.M., Kossatz, U., Chen, X., Firpo, E., Grunwald, V., Kamino, K., Wilkens, L., Lehmann, U., Buer, J., Geffers, R., Kubicka, S., Manns, M.P., Porter, P.L., Roberts, J., and Malek, N.P. 

A pathway in quiescent cells that controls p27Kip1 stability, subcellular localization, and tumor suppression.
Genes Dev., vol. 20: 47-64, 2006.
Besson, A., Gurian-West, M., Chen, X., Kelly-Spratt, K.S., Kemp, C.J., and Roberts, J.M. 

p27Kip1 independently promotes neuronal differentiation and migration in the cerebral cortex.
Genes Dev., vol. 20: 1511-1524, 2006.
Nguyen, L., Besson, A., Heng, J., Schurmans, C., Teboul, L., Philpott, A., Roberts, J.M., and Guillemont, F.

A new description of cellular quiescence.
PLOS Biol., vol. 4(3): 1-21, 2006.
Coller, H.A., Liyun, S., and Roberts, J.M.

Cyclin I protects podocytes from apoptosis.
J. Biol. Chem., vol. 281(38): 28048-28057, 2006.
Griffin, S.V., Olivier, J.P., Pippin, J.W., Roberts, J.M., and Shankland, S.J.

Coupling cell cycle exit, neuronal differentiation and migration in cortical neurogenesis.
Cell Cycle, vol. 5(20): 2314-2320, 2006.
Nguyen, L., Besson, A., Roberts, J.M., and Guillemot, F.

p27Kip1 and cyclin E expression and breast cancer survival after treatment with adjuvant chemotherapy.
J. Natl. Cancer Inst., vol. 98(23): 1723-1731, 2006.
Porter, P.L., Barlow, W.E., Yeh, I.T., Lin, M.G., Yuan, X.P., Donato, E., Sledge, G.W., Shapiro, C.L., Ingle, J.N., Haskell, C.M., Albain, K.S., Roberts, J.M., Livingston, R.B., and Hayes, D.F.

A mouse model for cyclin E-dependent genetic instability and tumorigenesis.
Cancer Cell, vol. 8(1): 35-47, 2005.
Loeb, K.R., Kostner, H., Firpo, E., Norwood, T., Tsuchiva, K.D., Clurman, B.E., and Roberts, J.M.

Regulation of the cytoskeleton: an oncogenic function for CDK inhibitors.
Nat. Rev. Cancer, vol. 4: 948-955, 2004a.
Besson, A., Assoian, R.K., and Roberts, J.M. 

p27Kip1 modulates cell migration through the regulation of RhoA activation.
Genes Dev., vol. 18: 862-876, 2004b.
Besson, A., Gurian-West, M., Schmidt, A., Hall, A., and Roberts, J.M.

Living with or without cyclins and cyclin-dependent kinases.
Genes Dev., vol. 18: 2699-2711, 2004.
Sherr, C.J., and Roberts, J.M.

Regulation of cyclin-dependent kinase activity during mitotic exit and maintenance of genome instability by p21, p27, p107.
Proc. Natl. Acad. Sci. USA, vol. 101(13): 4465-4470, 2004.
Chibazakura, T., McGrew, S.G., Cooper, J.A., Yoshikawa, H., and Roberts, J.M.

N-Acetylation and Ubiquitin-Independent proteasomal degradation of p21Cip1.
Mol. Cell, vol. 16: 839-847, 2004.
Chen, X., Yong, C., Bloecher, A., Aebersold, R., Clurman, B.E., and Roberts, J.M.

Cooperative regulation of the cell division cycle by the protein kinases RAF and Akt.
Mol. Cell Biol., vol. 24(24): 10868-10881, 2004.
Mirza, A.M., Gysin, S., Malek, N., Nakayama, K., Roberts, J.M., and McMahon, M.

Telomerase modulates expression of growth-controlling genes and enhances cell proliferation.
Nat. Cell Biol., vol. 5: 474-479, 2003.
Smith, L.L., Coller, H.A., and Roberts, J.M.

Multisite phosphorylation by Cdk2 and GSK3 controls cyclin E degradation.
Mol. Cell, vol. 12: 381-392, 2003.
Welcker, M., Singer, J., Loeb, K.R., Grim, J., Bloecher, A.,  Gurien-West, M., Clurman, B.E., and Roberts, J.M.

Bared essentials of Cdk2 and cyclin E.
Nat. Genetics, vol. 35: 9-10, 2003.
Roberts, J.M., and Sherr, J.

Antigen-specific dose-dependent system for the study of an inheritable and reversible phenotype in mouse CD4+ cells.
Immunology, vol. 107: 480-488, 2002.
Firpo, E.J., Kong, R.K., A., Zhou, Q., Rudensky, A.Y., Roberts, J.A., and Franza, R.

Oscillation sensation.
Nature, vol. 418: 495-496, 2002.
Morgan, D.O., and Roberts, J.A.

MAD1 and p27(Kip1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-Cdk2 activity.
Mol. Cell Biol., vol. 22(9): 3014-3023, 2002.
McArthur, G.A., Foley, K.P., Fero, M.L., Walkley, C.R., Deans, J.R., Roberts, J.M., and Eisenman, R.N.

The subcellular localization of cyclin dependent kinase 2 determines the fate of mesangial cells: role in apoptosis and proliferation.
Oncogene, vol. 21(11): 1750-1758, 2002.
Hiromura, K., Pippin, J.W., Blonski, M.J., Roberts, J.M., and Shankland, S.J.

A mouse knock-in model exposes sequential proteolytic pathways that regulate p27Kip1 in G1 and S phase.
Nature, vol. 413: 323--327, 2001.
Malek, N.P., Sundberg, H., McGrew, S., Nakayama, K., Kyriakides, T.R., Roberts, J.M., and Kyriakidis, T.R.

Retinoblastoma protein: Combating algal bloom.
Current Biol., vol. 11: R824-R827, 2001.
Cross, F.R., and Roberts, J.M.

Tof1p regulates DNA responses during S phase in Saccharomyces cerevisae.
Genetics, vol. 157(2): 567-577, 2001.
Foss, E.

Proteasomal turnover of p21Cip1 does not requiere p21Cip1 ubiquitination.
Mol. Cell., vol. 5: 403-410, 2000.
Sheaff, R.J., Singer, J.D., Swanger, J., Smitherman, M., Roberts, J.M., and Clurman, B.E.

Evolving ideas about cyclins.
Cell, vol. 98: 129-132, 1999.
Roberts, J.

CDK inhibitors, positive and negative regulators of G1-phase progression.
Genes Dev., vol. 13: 1501-1512, 1999.
Sherr, C.J., and Roberts, J.

A new pathway for mitogen-dependent Cdk2 regulation uncovered in p27Kip1-deficient cells.
Curr. Biol., vol. 9(4): 163-173, 1999.
Coats, S., Whyte, P., Fero, M.L., Lacy, S., Chung, G., Randel, E., Firpo, E., and Roberts, J..

Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells.
Genes Dev., vol. 13: 2375-2387, 1999.
Singer, J.D., Gurian-West, M., Clurman, B., and Roberts, J.

Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.
Proc. Natl. Acad. Sci. USA, vol. 96(7): 4084-4088, 1999.
Lowenheim, H., Furness, D.N., Kil, J., Zinn, C., Gultig, K., Fero, M.L., Frost, D., Gummer, A.W., Roberts, J.M., Rubel, E.W., Hackney, C.M., and Zenner, H.P.

The p21(Cip1) and p27(Kip1 CDK inhibitors are essential activators of cyclin D-dependent kinases in murine fibroblats.
EMBO J., vol. 18(6): 1571-1583, 1999.
Cheng, M., Olivier, P., Diehl, J.A., Fero, M., Roussel, M.F., Roberts, J.M., and Sherr, C.J.

Modulation of apoptosis by the cyclin-dependent kinase inhibitor p27(Kip1).
J. Clin. Invest., vol. 103(5): 597-604, 1999.
Hiromura, K., Pippin, J.W., Fero, M.L., Roberts, J.M., and Shankland, S.J.

The murine gene p27Kip1 is haplo-insufficient for tumour suppression.
Nature, vol. 396: 177-180, 1998.
Fero, M.L., Randel, E., Gurley, K.E., Roberts, J.M., and Kemp, C.J.

The Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade.
Mol. Cell, vol. 1: 553-563, 1998.
Levkau, B., Koyama, H., Raines, E.W., Clurman, B.E., Herren, B., Orth, K., Roberts, J.M., and Ross, R.

The cyclin-dependent kinase inhibitor p27Kip1 safeguards against inflammatory injury.
Nat. Med., vol. 4: 575-580, 1998.
Ophascharoensuk, V., Fero, M.L., Hughes, J., Roberts, J.M., and Shankland, S.J.

CDC16 controls initiation at chromosome replication origins.
Mol. Cell, vol. 1(3): 457-463, 1998.
Heichman, K.A., and Roberts, J.M.

Regulation of G1 phase.
Results Probl. Cell Differ., vol. 22: 1-34, 1998.
Sheaff, R.J., and Roberts, J.M.

p27Kip1 alters the response of cells to mitogen and is part of a cell-intrinsic timer that arrests the cell cycle and initiates differentiation.
Curr. Biol., vol. 8(8): 431-440, 1998.
Durand, B., Fero, M.L., Roberts, J.M., and Raff, M.C.

Identification of a substrate-targeting domain in cyclin E necessary for phosphorylation of the retinoblastoma protein.
PNAS USA, vol. 95(5): 2535-2540, 1998.
Kelly, B.L., Wolfe, K.G., and Roberts, J.M.

Expression of cell cycle regulators p27Kip1 and cyclin E, alone and in combination, correlate with survival in young breast cancer patients.
Nature Med., vol. 3: 222-225, 1997.
Potter, L.P., Malone, K.E., Heagerty, P.Y., Alexander G.M., Gatti, L.A. Firpo, E.J., Daling, J.R., and Roberts, J.

Inactivation of MyoD-mediated expression of p21 in tumor cell lines.
Cell Growth Differ., vol. 8(11): 1151--1160, 1997.
Otten, A.D., Firpo, E.J., Gerber, A.N., Brody, L.L., Roberts, J.M., and Tapscott, S.J.

Mesangial cell proliferation mediated by PDGF and bFGF is determined by levels of the cyclin kinase inhibitor p27Kip1.
Kidney Int., vol. 51(4): 1088-1099, 1997.
Shankland, S.J., Pippin, J., Flanagan, M., Coats, S.R., Nangaku, M., Gordon, K.L., Roberts, J.M., Couser, W.G., and Jonhson, R.J.

p57Kip2 targeted disruption and Beckwith-Wiedemann syndrome: is the inhibitor just a contributor?
Bioessays, vol. 19(10): 839-842, 1997.
Swanger, W.J., and Roberts, J.M.

Cyclin E-CDK2 is a regulator of p27Kip2.
Genes Dev., vol. 11(11): 1464-1478, 1997.
Sheaff, R.J., Groudine, M, Gordon, M., Roberts, J.M., and Clurman, B.E.

Association of cyclin A and cdk2 with SV40 DNA in replication initiation complexes is cell cycle dependent.
Chromosoma, vol. 105(6): 349-359, 1997.
Cannella, D., Roberts, J.M., and Fotedar, R.

A Syndrome of multiorgan hyperplasia with features of gigantism, tumorigenesis, and female sterility in p27Kip1-Deficient mice.
Cell, vol. 85(5):733-744, 1996.
Fero, M.L., Rivkin M., Tasch, M., Potter, P., Carow, C.E., Firpo, E., Polyak, K., Tsai, L-H., Broudy, V., Perlmutter, R.M., Kaushansky, K., and Roberts, J.M. 

Requirement of p27Kip1 for restriction point control of the fibroblast cell cycle.
Science, vol. 272: 877-880, 1996.
Coats, S., Flannagan, W.M., Nourse, J., and Roberts, J.

The tumor suppressor gene Brca1 is required for embryonic cellular proliferation in the mouse.
Cell, vol. 85(7): 1009-1023, 1996.
Hakem, R., de la Pompa, J.L., Sirard, C., Mo, R., Woo, M., Hakem, A., Wakeham, A., Potter, J., Reitmair, A., Billia, F., Firpo, E., Hui, C.C., Roberts, J.M., Rossant, J., and Mak, T.W.

Turnover of cyclin E by the ubiquitin-proteasome pathway is regulated by cdk2 binding and cyclin phosphorylation.
Genes Dev., vol. 10: 1979-1990, 1996.
Clurman, B.E., Sheaff, R.J., Thress, K., Groudine, M., and Roberts, J.M.

Regulation of cyclin E transcription by E2F and retinoblastoma protein.
Oncogene, vol. 12: 1173-1180, 1996.
Geng, Y., Eaton, E.N., Picon, M., Roberts, J.M., Lundberg, A.S., Gifford, A., Sardet, C., and Weinberg, R.A.

The yeast CDC16 and CD27 genes restrict DNA replication to once per cell cycle.
Cell, vol. 85(1): 39-48, 1996.
Heichman, K.A., and Roberts, J.M.

Changes in cell-cycle protein expression during experimental mesangial proliferative glomerulomephritis.
Kidney Int., vol. 50(4): 1230-1239, 1996.
Shankland, S.J., Hugo, C., Coats, S.R., Nangaku, M., Pichler, R.H., Gordon, K.L., Pippin, J., Roberts, J.M., Couser W.G., and Jonhson, R.J.

Adhesion-dependent cell cycle progression linked to the expression of cyclin D1, activation of cyclin E-cdk2, and phosphorilation of the retinoblastoma protein.
J. Cell Biol., vol. 133(2): 391-403, 1996.
Zhu, X., Ohtsubo, M., Bohmer, R.M., Roberts, J.M., and Assoian, R.K.

Deregulation of cell cycle control in hematologic malignancies.
Curr. Opin. Hematol., vol. 3(4): 315-320, 1996.
Clurman, B.E., Roberts, J.M., and Groudine, M.

Inhibitors of mammalian G1 cyclin-dependent kinases.
Genes Dev.,, vol. 9: 1149-1163, 1995.
Sherr, C., and Roberts, J.

Human cyclin E, a nuclear protein essential for the G1-to-S phase transition.
Mol. Cell Biol., vol. 15(5): 2612-2624, 1995.
Ohtsubo, M., Theodoras, A.M., Schumacher, J., Roberts, J.M., and Pagano, M.

Cell cycle and cancer.
J. Natl. Cancer Inst., vol. 87(20): 1499-1501, 1995.
Clurman, B.E., and Roberts, J.M.

Cell cycle 1995: constructing cell physiology with molecular buildings blocks.
Curr. Opin. Cell Biol., vol. 7(6): 769-772, 1995.
Massague, J., and Roberts, J.M.

Inactivation of a Cdk2 inhibitor during IL-2 induced proliferation of human T-lymphocytes
Mol. Cell. Biol, vol. 14: 4889-4901, 1994.
Firpo, E., Koff, A., Solomon, R., and Roberts, J.

IL-2 mediated elimination of the p27Kip1 cyclin-Cdk kinase inhibitor prevented by rapamycin.
Nature, vol. 372: 570-573, 1994.
Nourse, J., Firpo, E., Flanagan M., Meyerson, M., Polyak, K., Lee, M-H., Massague, J., Crabtree, G., and Roberts, J.

p27Kip1, a cyclin-Cdk inhibitor, links transforming growth factor-ß and contact inhibition to cell cycle arrest.
Genes Dev., vol. 8: 9-22, 1994a.
Polyak, K., Kato, J-Y., Solomon, M.J., Sherr, C.J., Massague, J., Roberts, J.M., and Koff, A.

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals.
Cell, vol. 78: 59-66, 1994b.
Polyak, K., Lee, M-H., Erdjument-Bromage, H., Koff, A., Roberts, J., Tempst, P., and Massague, J.

Cyclins, Cdks, and cyclin kinase inhibitors.
Cold Spring Habor Symp. Quant. Biol., vol. 59: 31-38, 1994.
Roberts, J.M, Koff, A., Polyak, K., Firpo, E., Collins, S., Ohtsubo, M., and Massague, J.

Rules to replicate by.
Cold Spring Habor Symp. Quant. Biol., vol. 59: 31-38, 1994.
Heichman, K.A., and Roberts, J.M.

Negative regulation of G1 in mammalian cells: inhibition of cyclin E-dependent kinase by TGB-ß.
Science, vol. 260:536-539, 1993.
Koff A., Ohtsuki, M., Polyak, K., Roberts, J., and Massague, J.

Cyclin-dependent regulation of G1 in mammalian fibroblasts.
Science, vol. 259:1908-1910, 1993.
Ohtsubo, M., and Roberts, J.M.

A link between cyclin A expression and adhesion-dependent cell cycle progression.
Science, vol. 262(5139):1572-1575, 1993.
Guadagno, T.M., Ohtsubo, M., Roberts, J.M., and Associan, R.K.

Turning DNA replication on and off.
Curr. Opin. Cell Biol., vol. 5(2):201-206, 1993.
Roberts, J.M.

Activation of the p34Cdc2 protein kinase at the start of S phase in the human cell cycle.
Mol. Biol. Cell, vol. 3(4): 389-401, 1992.
Marracino, R.L., Firpo, E.J., and Roberts, J.

Formation and activation of a cyclin E-Cdk2 complex during the G1 phase of the human cell cycle.
Science, vol. 257: 1689-1694, 1992.
Koff, A., Giordano, A., Desai, D., Yamashita, K., Harper, J.W., Elledge, S., Nishimoto, T., Morgan, D.O., Franza, B.R., and Roberts, J.

Cell cycle regulated phosphorylation of RPA-32 occurs within the replication initiation complex.
EMBO J., vol. 11(6): 2177-2187, 1992.
Fotedar, R., and Roberts, J.M.

Association of p34cdc2 with replicating DNA.
Cold Spring Harb. Symp. Quant. Biol., vol. 56: 325-333, 1981.
Fotedar, R., and Roberts, J.M.