Publications

• Lin, C.-H., Jackson, A.L., Guo, J., Linsley, P.S., and Eisenman, R.N. Myc-regulated microRNAs attenuate embryonic stem cell differentiation. EMBO Journal. In press. 2009

• Freie, B.W. and Eisenman, R.N. Ratcheting Myc. Cancer Cell 22:2755-2766. 2008

• Eilers, M., and Eisenman, R.N. Myc’s Broad Reach. Genes Dev. 22:2755-2766. 2008

• Laurenti, E., Varnum-Finney, B., Wilson, A., Ferrero, I., Blanco-Rose, W., Ehninger, A., Knoepfler, P., Cheng, P.-F., MacDonald, R., Eisenman, R., Bernstein, I, and Trumpp, A. Hematopoietic stem cell function and survival depend on c-Myc and N-Myc activity. Cell Stem Cell 3:611-624. 2008

• Martins, R.A., Zindy, F., Donovan, S., Zhang, J., Pounds, S., Wey, A., Knoepfler, P.S., Eisenman, R.N., Roussel, M.F., and Dyer, M.A. N-myc coordinates retinal growth with eye size during mouse development. Genes Dev 22(2): 179-193. 2008

• Pierce, S.B., Yost, C., Anderson, S.A., Flynn, E.M., Delrow, J., and Eisenman, R.N. Drosophila growth and development in the absence of dMyc and dMnt. Dev Biol 315(2): 303-316. 2007

• Secombe, J. et al. The Trithorax group protein Lid is a trimethyl histone H3-K4 demethylase required for dMyc-induced cell growth., Genes & Development, 21, 537. 2007

• Knoepfler, P. S. et al. Myc influences global chromatin structure, EMBO Journal, 25, 2723. 2006

• Hatton, BA; et al. N-myc Is an Essential Downstream Effector of Shh Signaling during both Normal and Neoplastic Cerebellar Growth, Cancer Research, 66, 8655. 2006

• Zindy, F. et al. N-Myc and the cyclin-dependent kinase inhibitors, p18Ink4c and p27Kip1, coordinately regulate cerebellar development, PNAS, 103, 11579. 2006
  
• Mendrysa, S.M., O’Leary, K.A., McElwee, M.K., Michalowski, J., Eisenman, R.N., Powell, D.A. and Perry, M.E. Tumor Suppression and Normal Aging in Mice with Constitutively High p53 Activity. Genes Dev. 20: 16-21 2006.
  
• Shiio Y., Rose D. W., Donohoe S., Aebersold R., and Eisenman R. N. Identification and characterization of SAP25, a novel component of the mSin3 corepressor complex. Mol. Cell Biol. 26: 1386-1397. 2006.
  
• Grandori C, Gomez-Roman N, Felton-Edkins ZA, Ngouenet C, Galloway DA, Eisenman RN, White RJ, C-Myc Binds to Human Ribosomal DNA and Stimulates Transcription of RRNA Genes By RNA Polymerase I., Nature Cell Biology, 7(3):311-8, Mar 2005


• Orian, A., Grewal, S.S., Knoepfler, P.S., Edgar, B.A., Parkhurst, S.M. and Eisenman, R.N. Genomic Binding and Transcriptional Regulation by the Drosophila Myc and Mnt Transcription Factors.  Cold Spring Harbor Symp. Quant. Biol. 70.  2005
• Grewal SS, Li L, Orian A, Eisenman RN, Edgar BA, Myc-dependent Regulation of Ribosomal RNA Synthesis During Drosophila Development., Nature Cell Biology, 7(3):295-302, Mar 2005

• Okubo T, Knoepfler PS, Eisenman RN, Hogan BL, Nmyc Plays An Essential Role During Lung Development As a Dosage-sensitive Regulator of Progenitor Cell Proliferation and Differentiation., Development (cambridge, England), 132(6):1363-74, Mar 2005

• Welcker M, Orian A, Grim JA, Eisenman RN, Clurman BE, A Nucleolar Isoform of the Fbw7 Ubiquitin Ligase Regulates C-Myc and Cell Size., Current Biology : Cb, 14(20):1852-7, Oct 2004

• Swanson KA, Knoepfler PS, Huang K, Kang RS, Cowley SM, Laherty CD, Eisenman RN, Radhakrishnan I, HBP1 and Mad1 Repressors Bind the Sin3 Corepressor PAH2 Domain With Opposite Helical Orientations., Nat Struct Mol Biol, 11(8):738-46, Aug 2004

• Welcker M, Orian A, Jin J, Grim JA, Harper JW, Eisenman RN, Clurman BE, The Fbw7 Tumor Suppressor Regulates Glycogen Synthase Kinase 3 Phosphorylation-dependent C-Myc Protein Degradation., Proceedings of the National Academy of Sciences of the United States of America., 101(24):9085-90, Jun 2004

• Pierce SB, Yost C, Britton JS, Loo LW, Flynn EM, Edgar BA, Eisenman RN, DMyc Is Required for Larval Growth and Endoreplication in Drosophila., Development (cambridge, England), 131(10):2317-27, May 2004

• Cowley SM, Kang RS, Frangioni JV, Yada JJ, DeGrand AM, Radhakrishnan I, Eisenman RN, Functional Analysis of the Mad1-mSin3A Repressor-corepressor Interaction Reveals Determinants of Specificity, Affinity, and Transcriptional Response., Molecular and Cellular Biology, 24(7):2698-709, Apr 2004

• Secombe J, Pierce SB, Eisenman RN, Myc: a Weapon of Mass Destruction., Cell, 117(2):153-6, Apr 2004

• Gomez-Roman N, Grandori C, Eisenman RN, White RJ, Direct activation of RNA polymerase III transcription by c-Myc, Nature, 421(6920):290-4, January 2003

• Shiio Y, Donohoe S, Yi EC, Goodlett DR, Aebersold R, Eisenman RN, Quantitative proteomic analysis of Myc oncoprotein function, The Embo Journal, 21(19):5088-96, October 2002

• Iritani BM, Delrow J, Grandori C, Gomez I, Klacking M, Carlos LS, Eisenman RN, Modulation of T-lymphocyte development, growth and cell size by the Myc antagonist and transcriptional repressor Mad1, The Embo Journal, 21(18):4820-30, September 2002

• McArthur GA, Foley KP, Fero ML, Walkley CR, Deans AJ, Roberts JM, Eisenman RN, MAD1 and p27(KIP1) cooperate to promote terminal differentiation of granulocytes and to inhibit Myc expression and cyclin E-CDK2 activity, Molecular and Cellular Biology, 22(9):3014-23, May 2002

• Eisenman RN, Deconstructing myc, Genes and Development, 15(16):2023-30, August 2001

• Brubaker K, Cowley SM, Huang K, Loo L, Yochum GS, Ayer DE, Eisenman RN, Radhakrishnan I, Solution structure of the interacting domains of the Mad-Sin3 complex: Implications for recruitment of a chromatin-modifying complex, Cell, 103(4):655-65, 2000

• Hurlin PJ, Steingrimsson E, Copeland NG, Jenkins NA, Eisenman RN, Mga, a dual-specificity transcription factor that interacts with Max and contains a T-domain DNA-binding motif, Embo Journal, 18(24):7019-28, December 1999

• Johnston LA, Prober DA, Edgar BA, Eisenman RN, Gallant P, Drosophila myc regulates cellular growth during development, Cell, 98(6):779-90, September 1999

• Laherty CD, Billin AN, Lavinsky RM, Yochum GS, Bush AC, Sun JM, Mullen TM, Davie JR, Rose DW, Glass CK, Rosenfeld MG, Ayer DE, Eisenman RN, SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors, Molecular Cell, 2(1):33-42, July 1998

• Foley KP, McArthur GA, Queva C, Hurlin PJ, Soriano P, Eisenman RN, Targeted disruption of the MYC antagonist MAD1 inhibits cell cycle exit during granulocyte differentiation, Embo Journal, 17(3):774-85, February 1998

• Laherty CD, Yang WM, Sun JM, Davie JR, Seto E, Eisenman RN, Histone deacetylases associated with the mSin3 corepressor mediate mad transcriptional repression, Cell, 89(3):349-56, May 1997