The Biomarker Lab, within the Cancer Prevention Program in the Public Health Sciences Division, supports epidemiological & clinical studies. We collaborate with researchers both internally at the Fred Hutchinson Cancer Research Center and at other institutions such as Harvard, UCSF, University of Washington, and University of Illinois College of Medicine. The large studies we have participated in include SELECT (Selenium and Vitamin E Cancer Prevention Study), PCPT (Prostate Cancer Prevention Trial), CHS (The Cardiovascular Health Study), and WHI (Women’s Health Initiative).
We specialize in assays related to nutritional biochemistry and the discovery & validation of cancer risk biomarkers. We develop, validate, and perform a wide range of assays from lipids & vitamins, to cytokines, and global methylation. The assay platforms we use include chromatography, chemistry analyzer, atomic absorption spectroscopy, ELISA, Luminex, and etc. We implement rigorous quality control procedures from sample tracking to data review and management. We participate and have had excellent records in the NIST fat-soluble vitamins/carotenoids in serum exercises and the DEQAS Vitamin D External Quality Assessment Scheme, which are national or international QA programs.
Our work with collaborators often starts in the proposal development stage, including technical consultation, protocols, budgets, and etc. We also participate in the interpretation of assay results and preparation of manuscripts.
The Director of the Biomarker Lab, Xiaoling Song, is a Biochemist and Molecular Biologist. She earned a Ph.D. in Biochemistry & Molecular Biology from the UT Southwestern Medical Center at Dallas, Texas. She has had over 19 years of laboratory research experience, including 11 years leading research labs in both academic and industry settings. The scientific staff of the lab is consisted of 5 well-trained technicians. They hold either a Master or Bachelor’s degree in biological/chemical disciplines, and their lab research experience ranges from 5 to over 20 years.
Takata Y, Kristal AR, King IB, Song X, Diamond AM, Foster CB, Hutter CM, Hsu L, Duggan DJ, Langer RD, Petrovitch H, Shikany JM, Vaughan TL, Lampe JW, Prentice RL, Peters R. Serum Selenium Concentration and Genetic Variation in Selenoenzymes and Risk of Colorectal Cancer: Primary Analysis from The Women’s Health Initiative Observational Study and Meta-Analysis in Men and Women. Cancer Epidemiology, Biomarkers & Prevention 20(9):1822-30, 2011
Wu J, Lemaitre RN, Imamura F, King IB, Song X, Spiegelman D, Siscovick DS, Mozaffarian D. Fatty Acids in the De Novo Lipogenesis Pathway and Risk of Coronary Heart Disease: the Cardiovascular Health Study. The American Journal of Clinical Nutrition 94(2):431-8, 2011
DjoussÚ L, Biggs ML, Lemaitre RN, King IB, Song X, Ix JH, Mukamal KJ, Siscovick DS, Mozaffarian D. Plasma omega-3 fatty acids and incident diabetes in older adults. The American Journal of Clinical Nutrition 94(2):527-33, 2011
Mozaffarian D, Lemaitre RN, King IB, Song X, Spiegelman D, Sacks FM, Rimm EB, Siscovick DS. Circulating Long-Chain Omega-3 Fatty Acids and Incidence of Congestive Heart Failure in Older Adults: the Cardiovascular Health Study. Annals of Internal Medicine 155(3):160-70, 2011
Kristal AR, Till C, Platz E, Song X, King IB, Neuhouser ML, Thompson IM. Serum Lycopene Concentration and Prostate Cancer Risk: Results from the Prostate Cancer Prevention Trial. Cancer Epidemiology, Biomarkers & Prevention 20(4):638-46, 2011
Brasky TM, Till C, White E, Neuhouser ML, Song X, Goodman PJ, Thompson IM, King IB, Kristal AR. Serum Phospholipid Fatty Acids and Prostate Cancer Risk in the Prostate Cancer Prevention Trial. American Journal of Epidemiology 173(12):1429-39, 2011
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Trans-Palmitoleic Acid, Metabolic Risk Factors, and New-Onset Diabetes in US Adults. Annals of Internal Medicine 153(12): 790-9, 2010
Mozaffarian D, Cao H, King IB, Lemaitre RN, Song X, Siscovick DS, Hotamisligil GS. Circulating palmitoleic acid and risk of metabolic abnormalities and new-onset diabetes. The American Journal of clinical Nutrition 92(6):1350-8, 2010
Micha R, King IB, Lemaitre RN, Rimm E, Sacks F, Song X, Siscovick DS, Mozaffarian D. Food sources of individual plasma phospholipid trans fatty acid isomers: the Cardiovascular Health Study. The American Journal of clinical Nutrition 91(4):883-93, 2010
Trobridge P, Knoblaugh S, Washington MK, Munoz NM, Tsuchiya KD, Rojas A, Song X, Ulrich CM, Sasazuki T, Shirasawa S, Grady WM. TGF-▀ receptor inactivation and mutant Kras induce intestinal neoplasms in mice via a ▀-catenin independent pathway. Gastroenterology 136(5):1680-8, 2009