Publications

  • Vermulst M, Bielas JH, Loeb LA. Quantification of random mutations in the mitochondrial genome. Methods. 2008 Dec;46(4):263-8.

  • Loeb LA, Bielas JH, Beckman RA. Cancers exhibit a mutator phenotype: Clinical implications. Cancer Res. 2008 May 15;68(10):3551-7.
        • Counterpoint: Bodmer W. Genetic instability is not a requirement for tumor development. Cancer Res. 2008 May 15;68(10):3557.
        • Counterpoint Response: Loeb LA, Bielas JH, Beckman RA. Cancer Res. 2008 May 15;68(10):3560-1.
  • Vermulst M, Wanagat J, Kujoth GC, Bielas JH, Rabinovitch PS, Prolla TA, Loeb LA. DNA deletions and clonal mutations drive premature aging in mitochondrial mutator mice. Nat Genet. 2008 Apr;40(4):392-4.
  • Vermulst M, Bielas JH, Kujoth GC, Ladiges WC, Rabinovitch PS, Prolla TA, Loeb LA. Mitochondrial point mutations do not limit the natural lifespan of mice. Nat Genet. 2007 Apr;39(4):540-3.
        • Associated Commentary: Khrapko K, Vijg J. Mitochondrial DNA mutations and aging: a case closed? Nat Genet. 2007 Apr;39(4):445-6.
  • Bielas JH, Venkatesan RN, Loeb LA. LOH-proficient embryonic stem cells: a model of cancer progenitor cells? Trends Genet. 2007 Apr;23(4):154-7.
  • Loeb LA, Bielas JH. Limits to the Human Cancer Genome Project? Science. 2007 Feb 9;315(5813):762; author reply 764-5.
  • Bielas JH, Loeb KR, Rubin BP, True LD, Loeb LA. Human cancers express a mutator phenotype. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18238-42.
        • Associated Commentary: Klein CA. Random mutations, selected mutations: A PIN opens the door to new genetic landscapes. Proc Natl Acad Sci U S A. 2006 Nov 28;103(48):18033-4.
  • Bielas JH. Non-transcribed strand repair revealed in quiescent cells. Mutagenesis. 2006 Jan;21(1):49-53.
  • Venkatesan RN, Bielas JH, Loeb LA. Generation of mutator mutants during carcinogenesis. DNA Repair (Amst). 2006 Mar 7;5(3):294-302.
  •  Bielas JH, Loeb LA. Quantification of random genomic mutations. Nat Methods. 2005 Apr;2(4):285-90.
          • In This Issue: Quantifying random mutations. Nat Methods. 2005 Apr;2(4):235.
  • Heddle JA, Bielas JH. Unifying concept of DNA repair: the polymerase scanning hypothesis. Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):143-9.
  • Bielas JH, Loeb LA. Mutator phenotype in cancer: timing and perspectives. Environ Mol Mutagen. 2005 Mar-Apr;45(2-3):206-13.
  • Bielas JH, Heddle JA. Quiescent murine cells lack global genomic repair but are proficient in transcription-coupled repair. DNA Repair (Amst). 2004 Jul 2;3(7):711-7.
  • Bielas JH, Heddle JA. Elevated mutagenesis and decreased DNA repair at a transgene are associated with proliferation but not apoptosis in p53-deficient cells. Proc Natl Acad Sci U S A. 2003 Oct 28;100(22):12853-8.
  • Bielas JH. A more efficient Big Blue protocol improves transgene rescue and accuracy in adduct and mutation measurement. Mutat Res. 2002 Jul 25;518(2):107-12.
  • Bielas JH, Heddle JA. Proliferation is necessary for both repair and mutation in transgenic mouse cells. Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11391-6.
        • Associated Commentary: O'Neill JP. DNA damage, DNA repair, cell proliferation, and DNA replication: How do gene mutations result? Proc Natl Acad Sci U S A. 2000 Oct 10;97(21):11137-9.
  • Swiger RR, Cosentino L, Shima N, Bielas JH, Cruz-Munoz W, Heddle JA. The cII locus in the MutaMouse system. Environ Mol Mutagen. 1999;34(2-3):201-7.

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