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Welcome to the online portal for Fred Hutchinson Cancer Research Center's scientific labs and research groups, including programs, projects and studies. Whether you're part of the scientific community or an interested member of the public, browse the links below to explore how our researchers are working toward the Hutchinson Center's mission: elimination of cancer and related diseases as causes of human suffering and death. Check back as we continue to add more sites.

Alphabetical Listing

Alphabetical listing of Center lab and research group websites

Name	Division	Description
Bedalov Lab	Clinical Research	The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.
Bielas Lab	Public Health Sciences	The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.
Biggins Lab	Basic Sciences	The Biggins Lab uses budding yeast to study chromosome segregation, the process by which chromosomes are distributed to new cells during cell division. Cells with an abnormal number of chromosomes are a hallmark of cancer and many birth defects.
Breeden Lab	Basic Sciences	The Breeden Lab investigates control of cell division in budding yeast, with a long-term goal of understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues.
Brent Lab	Basic Sciences	The Brent Lab studies how living cells sense, represent, transmit and act upon information to make decisions about their future states. The lab includes, experimentally, a social science component, in which lab members are encouraged to identify and analyze how their research outcomes and ongoing increases in biological knowledge might impact human affairs.
Chen Lab	Public Health Sciences	The Chu Chen Lab is conducting a hospital-based study to discover biomarkers that may improve diagnosis and prognosis of oral cancer. Several other studies focus on the links between genetic and environmental factors and development of, and/or survival from, tobacco-related and hormone-related cancers.
Clurman Lab	Clinical Research	The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.
Cooper Lab	Basic Sciences	The Cooper Lab investigates proteins involved in the signaling pathways that allow cells to communicate with each other. In particular, they study a protein called Disabled and the Src protein family to better understand how they regulate normal cell behavior and the transformation of normal cells to cancer cells.
Eisenman Lab	Basic Sciences	The Eisenman Lab studies how cell proliferation, growth, and differentiation are regulated through the actions of transcriptional networks, and how this regulation is undermined during tumor progression. The lab employs the tools of molecular biology as well as mammalian and Drosophila genetics to study basic mechanisms underlying normal and abnormal cellular functions.
Emerman Lab	Human Biology	The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.
Etzioni Lab	Public Health Sciences	The Etzioni Lab focuses on statistical methods for prostate-cancer studies, with the goal of improving guidelines for screening and treatment. Etzioni has assessed the likely impact of prostate-specific antigen testing on prostate-cancer incidence and mortality, and developed approaches for evaluating new cancer-screening biomarkers.
Fero Lab	Clinical Research	The Fero Lab studies how cell-cycle regulatory genes, p27 and Rb, control growth of tumors and normal tissues. Using novel mouse models and genomic technologies, they have discovered that cell cycle inhibitors and microRNAs regulate T-cell growth and differentiation, whereas mutations of these genes cooperate in lymphoma development.
Ferré-D'Amaré	Basic Sciences	The Ferré-D'Amaré Lab studies the structural underpinnings of RNA's biological functions using biochemistry, X-ray crystallography, and other biophysical techniques. Because RNA plays critical roles in the cell, both in health and disease, an atomic-level understanding of its function provides the basis for development of new therapies.
Galloway Lab	Human Biology	The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.
Geballe Lab	Human Biology	The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.
Gottschling Lab	Basic Sciences	The Gottschling Lab uses budding yeast as a model system to investigate fundamental questions in biology. One of their current areas of research interest is the striking link between increasing age and cancer incidence in humans.
Greenberg Lab	Clinical Research	The Greenberg Lab's guiding research goals are to understand the principles underlying T cell recognition of viruses and cancer cells, to determine why such responses often fail to eliminate the virus or cancer, and to develop cellular and molecular approaches that manipulate the immune system to treat human viral and malignant diseases.
Hahn Lab	Basic Sciences	The Hahn Lab studies the mechanism and regulation of transcription, the process of mRNA synthesis. Transcriptional regulation is one of the key steps controlling cell growth, differentiation and development, and defects cause many human illnesses. Using biochemistry, structural biology and molecular genetics, the lab focuses on the mechanism of the large conserved protein complexes that regulate and promote transcription.
Hanash Lab	Public Health Sciences	The Hanash Lab works to discover trace proteins called "markers" that are released into the blood by diseased tissues. The goal of this research is to develop more effective tests for early detection and diagnosis of lung, breast, colon, ovarian and pancreatic cancers as well as other common diseases.
Hansen Lab	Clinical Research
Heimfeld Lab	Clinical Research	The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.
Henikoff Lab	Basic Sciences	The Henikoff Lab studies the structure, function and evolution of chromosomes. They also develop tools for epigenomics and functional genomics.
Hockenbery Lab	Clinical Research	The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.
Kemp Lab	Human Biology	The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.
Kiem Lab	Clinical Research	The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.
Knudsen Lab	Public Health Sciences	The Knudsen Lab works to discover new biomarkers related to preventing, treating and predicting the course of prostate cancer. Other projects include understanding why this cancer spreads and assessing the effects of sulforaphane, an active ingredient in cruciferous vegetables, on prostate-cancer prevention.
Lampe Lab	Public Health Sciences	The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.
Li Lab	Public Health Sciences	Dr. Li uses a multidisciplinary approach to understand factors related to the causes and patient outcomes of breast cancer. Current projects include identifying new biomarkers that could be used for early detection, evaluating risk factors for different types of breast cancer, determining predictors of poor outcomes among breast cancer survivors, and assessing disparities in cancer stage, treatment and survival by race/ethnicity.
Madeleine Lab	Public Health Sciences	Dr. Madeleine's research focuses primarily on the molecular epidemiology of disease-causing agents, or pathogens, and the immune response to them that may be associated with cancer development and prognosis. Another interest is the role of chronic, undiagnosed immune system dysfunctions (such as those occurring with age, obesity, physical inactivity, hormone use, and UV exposure) in cancer development.
Malik Lab	Basic Sciences	The Malik Lab hunts for rapidly evolving proteins in order to understand how conflicts between genes affect human evolution. Such genetic conflicts can arise between virus and host genes as each fights for survival, but they can affect the function of essential genes, including those implicated in cancer.
McElrath Lab	Clinical Research	The McElrath Lab is dedicated to understanding the human immune response mechanisms in HIV infection and resistance in a way that can be translated into the development of an effective HIV vaccine.
McGregor Lab	Public Health Sciences	The McGregor Lab leads the Stress Management and Relaxation Training, or SMART, studies, which focus on understanding the effects of stress management on behavioral and biological factors that are relevant to cancer development, such as diet, exercise, immune function, DNA repair and cellular aging processes.
McIntosh Lab	Public Health Sciences	The McIntosh Lab develops primarily computational approaches for studying proteins and genomes in cancer. Their primary goal is to discover and evaluate diagnostic and early-detection biomarkers in serum, with research projects in ovarian, breast and pancreatic cancer and neurodegenerative diseases.
Miller Lab	Human Biology	The Miller Lab studies the basic biology of viral gene transfer. Their goals include developing gene-therapy treatments for lung diseases and generating induced pluripotent stem cells, which are useful for cell therapy in humans. Another major focus has been the jaagsiekte sheep retrovirus, which may provide insight into human lung cancer.
Moens Lab	Basic Sciences	The Moens Lab uses zebrafish as a model system to study how genes control the early development of the brain in vertebrates. Their work adds to our understanding of the causes of cancer because many of the genes that control embryonic development are the same ones that are wrongly regulated in cancer cells.
Mueller Lab	Public Health Sciences	Dr. Mueller's research focuses on the roles of maternal, gestational, early life factors, and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. She also studies reproductive history in relation to cancer and cancer survival in women, and reproductive outcomes among male and female childhood cancer survivors.
Neiman Lab	Basic Sciences
Nelson Lab	Clinical Research	The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.
Olson Lab	Clinical Research	The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.
Paddison Lab	Human Biology
Pagel Lab	Clinical Research	The Pagel lab focuses on the development and improvement of antibody therapies for leukemia and lymphoma, with the goal of decreasing toxic side effects while increasing the treatment's effectiveness. Our projects focus on advancing radioimmunotherapy through a pre-targeted method of delivering radiation to tumor sites.
Parkhurst Lab	Basic Sciences	The Parkhurst Lab studies how genes get turned on and off as fruit-fly embryos develop and how errors in this process can lead to cancer and other diseases. They also investigate wound healing and complex signals involving proteins that can affect a cell's "skeletal" structure.
Paulovich Lab	Clinical Research	The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.
Peichel Lab	Human Biology	The Peichel Lab uses a small fish called the threespine stickleback as a model organism to conduct research aimed at identifying the genetic and molecular mechanisms that underlie evolutionary processes. Research topics include understanding evolution of the fish's behavior and sex chromosomes.
Pepe Lab	Public Health Sciences	The Pepe Lab develops guidelines and software to promote the use of sound statistical methods by scientists who are working to evaluate diagnostic or prognostic medical devices and biomarkers.
Peter Nelson Lab	Human Biology	Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.
Porter Lab	Human Biology	The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.
Press Lab	Clinical Research	Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.
Priess Lab	Basic Sciences	The Priess lab studies how cells coordinate their shape and fate during the development of complex tissues and organs. Most of these studies use the nematode C. elegans as a model organism.
Radich Lab	Clinical Research	The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.
Ramsey Lab	Public Health Sciences	Dr. Ramsey directs the Research and Economic Assessment in Cancer and Healthcare (REACH) group, which focuses on cutting-edge cost-effectiveness and outcomes research in cancer prevention and treatment. REACH also has experience in designing and performing cost-effectiveness analyses of drugs, devices and interventions, with an eye towards supporting public and private decision making to maximize health value under resource constraints.
Research Cell Bank	Clinical Research	The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.
Roberts Lab	Basic Sciences	The Roberts Lab has discovered key proteins that regulate cell division and explored how changes in cell-cycle proteins may inform the treatment of specific cancers. Current research focuses on the development of mouse models of human cancers.
Roth Lab	Basic Sciences	The Roth Lab studies suspended animation and metabolic hibernation as a means to temporarily halt, or "dial down," metabolism. One day such techniques may help to buy time for critically ill patients on organ-transplant lists and in trauma situations.
Shimamura Lab	Clinical Research	The Shimamura Lab works to understand the molecular mechanisms contributing to development of blood cells (hematopoiesis) and cancer (tumorigenesis), with the ultimate goal of informing rationally designed therapeutic strategies. Their research focuses particularly on genetic marrow failure syndromes.
Shou Lab	Basic Sciences	The Shou Lab uses experimental biology, mathematics and engineering to study a variety of biological problems. Research interests include how cooperative systems evolve despite threats from "cheaters" that consume benefits without paying a fair cost, and how cells cope with nutrient limitations.
Simon Lab	Clinical Research	The Simon Lab works toward identifying new anticancer drugs through a wide range of experimental techniques and systems, ranging from organic synthesis to genetic screens.
Smith Lab	Basic Sciences	The Smith Lab works to understand how genetic recombination and DNA repair are accomplished, and how they are regulated to occur at the proper place and time. As deviations in this process can result in birth defects and cancers, this work may lend insight into the causes of these diseases and ways of predicting or preventing them.
Spies Lab	Clinical Research	The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.
Stoddard Lab	Basic Sciences	The Stoddard Lab studies the structure and mechanism of enzymes, the body's catalysts of biological reactions, in order to harness them for use in biotechnology and medicine. The engineering and redesign of certain enzymes could be used in targeted therapies for genetic diseases such as hemophilia and cystic fibrosis.
Strong Lab	Basic Sciences	The Strong Lab analyzes the structure of proteins and protein-receptor complexes that control the immune system's response to disease. Building on the principles learned from these studies, they also participate in a collaborative project to design proteins for a vaccine to prevent AIDS.
Tang Lab	Public Health Sciences
Tapscott Lab	Human Biology	The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.
Thompson Studies	Public Health Sciences	Led by Dr. Beti Thompson, this research group works to understand why disparities in cancer incidence and survival rates exist among different populations, especially Latinos. The group also supports efforts to reduce other health disparities, including diabetes and pesticide exposure, in minority communities in the United States and abroad.
Trask Lab	Human Biology	The Trask Lab investigates the organization of the human genome to understand recent evolutionary change, assess normal genetic variation, and detect genetic abnormalities that contribute to cancer and other diseases.
Tsukiyama Lab	Basic Sciences	The Tsukiyama Lab studies chromatin, the complex of DNA and proteins that make up our chromosomes, and how chromatin structure controls essential processes that take place on DNA.
Ulrich Lab	Public Health Sciences
Van Gilst Lab	Basic Sciences	The Van Gilst Lab investigates the mechanics of two fundamentally distinct metabolic states in animals--those adopted while feeding and while fasting--and works to understand how those programs relate to key aspects of physiology, disease and aging.
Vasioukhin Lab	Human Biology	The Vasioukhin Lab works to better understand how individual cells work together to produce and maintain a normal mammalian organism. The underlying idea is that cancer can occur as a result of breakdowns in the mechanisms that regulate this communication.
Warren Lab	Clinical Research	The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.

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Lab Name	Division	Description	Keywords	Lab URL
Bedalov Lab	Clinical Research	The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.		bedalov/index.html
Bielas Lab	Public Health Sciences	The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.		bielas/index.html
Biggins Lab	Basic Sciences	The Biggins Lab uses budding yeast to study chromosome segregation, the process by which chromosomes are distributed to new cells during cell division. Cells with an abnormal number of chromosomes are a hallmark of cancer and many birth defects.	Biggins, Yeast, Cell cycle, Genetics, Cell biology, Ipl1/aurora protein kinase, CenH3 histone variant, Hutch, Fred Hutchinson, Basic sciences, Cytoskeleton, microtubules, kinetochores	biggins/index.html
Breeden Lab	Basic Sciences	The Breeden Lab investigates control of cell division in budding yeast, with a long-term goal of understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues.		breeden/index.html
Brent Lab	Basic Sciences	The Brent Lab studies how living cells sense, represent, transmit and act upon information to make decisions about their future states. The lab includes, experimentally, a social science component, in which lab members are encouraged to identify and analyze how their research outcomes and ongoing increases in biological knowledge might impact human affairs.		brent/index.html
Chen Lab	Public Health Sciences	The Chu Chen Lab is conducting a hospital-based study to discover biomarkers that may improve diagnosis and prognosis of oral cancer. Several other studies focus on the links between genetic and environmental factors and development of, and/or survival from, tobacco-related and hormone-related cancers.		chen/index.html
Clurman Lab	Clinical Research	The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.		clurman/index.html
Cooper Lab	Basic Sciences	The Cooper Lab investigates proteins involved in the signaling pathways that allow cells to communicate with each other. In particular, they study a protein called Disabled and the Src protein family to better understand how they regulate normal cell behavior and the transformation of normal cells to cancer cells.	Cooper, Yeast, Cell cycle, Genetics, Cell biology, Ipl1/aurora protein kinase, CenH3 histone variant, Hutch, Fred Hutchinson, Basic sciences, Cytoskeleton, microtubules, kinetochores	cooper/index.html
Eisenman Lab	Basic Sciences	The Eisenman Lab studies how cell proliferation, growth, and differentiation are regulated through the actions of transcriptional networks, and how this regulation is undermined during tumor progression. The lab employs the tools of molecular biology as well as mammalian and Drosophila genetics to study basic mechanisms underlying normal and abnormal cellular functions.		eisenman/index.html
Emerman Lab	Human Biology	The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.		emerman/index.html
Etzioni Lab	Public Health Sciences	The Etzioni Lab focuses on statistical methods for prostate-cancer studies, with the goal of improving guidelines for screening and treatment. Etzioni has assessed the likely impact of prostate-specific antigen testing on prostate-cancer incidence and mortality, and developed approaches for evaluating new cancer-screening biomarkers.		etzioni/index.html
Fero Lab	Clinical Research	The Fero Lab studies how cell-cycle regulatory genes, p27 and Rb, control growth of tumors and normal tissues. Using novel mouse models and genomic technologies, they have discovered that cell cycle inhibitors and microRNAs regulate T-cell growth and differentiation, whereas mutations of these genes cooperate in lymphoma development.		fero/index.html
Ferré-D'Amaré	Basic Sciences	The Ferré-D'Amaré Lab studies the structural underpinnings of RNA's biological functions using biochemistry, X-ray crystallography, and other biophysical techniques. Because RNA plays critical roles in the cell, both in health and disease, an atomic-level understanding of its function provides the basis for development of new therapies.		ferre/index.html
Galloway Lab	Human Biology	The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.		galloway/index.html
Geballe Lab	Human Biology	The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.		geballe/index.html
Gottschling Lab	Basic Sciences	The Gottschling Lab uses budding yeast as a model system to investigate fundamental questions in biology. One of their current areas of research interest is the striking link between increasing age and cancer incidence in humans.		gottschling/index.html
Greenberg Lab	Clinical Research	The Greenberg Lab's guiding research goals are to understand the principles underlying T cell recognition of viruses and cancer cells, to determine why such responses often fail to eliminate the virus or cancer, and to develop cellular and molecular approaches that manipulate the immune system to treat human viral and malignant diseases.		pgreenberg/index.html
Hahn Lab	Basic Sciences	The Hahn Lab studies the mechanism and regulation of transcription, the process of mRNA synthesis. Transcriptional regulation is one of the key steps controlling cell growth, differentiation and development, and defects cause many human illnesses. Using biochemistry, structural biology and molecular genetics, the lab focuses on the mechanism of the large conserved protein complexes that regulate and promote transcription.	polymerase II, polymerase III, RNA polymerase, TATA binding protein, TBP, TFIID, TFIIA, TFIIB, gene regulation, holoenzyme, biochemistry, genetics, structure, yeast, protein, DNA, mechanism, BRF, TFIIIC, TFIIIB, Zn-ribbon, Steven Hahn, Seattle, Fred Hutchinson, Howard Hughes, cancer, molecular, biology, saccharomyces cerevisiae, graduate study, Washington	hahn/index.html
Hanash Lab	Public Health Sciences	The Hanash Lab works to discover trace proteins called "markers" that are released into the blood by diseased tissues. The goal of this research is to develop more effective tests for early detection and diagnosis of lung, breast, colon, ovarian and pancreatic cancers as well as other common diseases.		hanash/index.html
Hansen Lab	Clinical Research		Hansen, John Hansen, Research Cell Bank, HIP, Transplant, GVHD	hansen/index.html
Heimfeld Lab	Clinical Research	The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.		heimfeld/index.html
Henikoff Lab	Basic Sciences	The Henikoff Lab studies the structure, function and evolution of chromosomes. They also develop tools for epigenomics and functional genomics.		henikoff/index.html
Hockenbery Lab	Clinical Research	The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.		hockenbery/index.html
Kemp Lab	Human Biology	The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.		kemp/index.html
Kiem Lab	Clinical Research	The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.		kiem/index.html
Knudsen Lab	Public Health Sciences	The Knudsen Lab works to discover new biomarkers related to preventing, treating and predicting the course of prostate cancer. Other projects include understanding why this cancer spreads and assessing the effects of sulforaphane, an active ingredient in cruciferous vegetables, on prostate-cancer prevention.		knudsen/index.html
Lampe Lab	Public Health Sciences	The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.		lampe/index.html
Li Lab	Public Health Sciences	Dr. Li uses a multidisciplinary approach to understand factors related to the causes and patient outcomes of breast cancer. Current projects include identifying new biomarkers that could be used for early detection, evaluating risk factors for different types of breast cancer, determining predictors of poor outcomes among breast cancer survivors, and assessing disparities in cancer stage, treatment and survival by race/ethnicity.		li/index.html
Madeleine Lab	Public Health Sciences	Dr. Madeleine's research focuses primarily on the molecular epidemiology of disease-causing agents, or pathogens, and the immune response to them that may be associated with cancer development and prognosis. Another interest is the role of chronic, undiagnosed immune system dysfunctions (such as those occurring with age, obesity, physical inactivity, hormone use, and UV exposure) in cancer development.		madeleine/index.html
Malik Lab	Basic Sciences	The Malik Lab hunts for rapidly evolving proteins in order to understand how conflicts between genes affect human evolution. Such genetic conflicts can arise between virus and host genes as each fights for survival, but they can affect the function of essential genes, including those implicated in cancer.	Malik, Hutch, Fred Hutchinson, Basic science, Biochemistry, Proteins, Bioinformatics, Biological Sciences, Cell Cycle, Chemical Engineering, Evolution, Genetics, Genomics, Molecular Biology, Phylogenetics, Plasmids, Retrovirus, 2 Micron Plasmid, Bioinformatics, Centromeres, Chromatin, Genomics, Mobile Genetic Elements, Molecular Evolution, Rapidly Evolving Proteins	malik/index.html
McElrath Lab	Clinical Research	The McElrath Lab is dedicated to understanding the human immune response mechanisms in HIV infection and resistance in a way that can be translated into the development of an effective HIV vaccine.		mcelrath/index.html
McGregor Lab	Public Health Sciences	The McGregor Lab leads the Stress Management and Relaxation Training, or SMART, studies, which focus on understanding the effects of stress management on behavioral and biological factors that are relevant to cancer development, such as diet, exercise, immune function, DNA repair and cellular aging processes.		mcgregor/index.html
McIntosh Lab	Public Health Sciences	The McIntosh Lab develops primarily computational approaches for studying proteins and genomes in cancer. Their primary goal is to discover and evaluate diagnostic and early-detection biomarkers in serum, with research projects in ovarian, breast and pancreatic cancer and neurodegenerative diseases.		mcintosh/index.html
Miller Lab	Human Biology	The Miller Lab studies the basic biology of viral gene transfer. Their goals include developing gene-therapy treatments for lung diseases and generating induced pluripotent stem cells, which are useful for cell therapy in humans. Another major focus has been the jaagsiekte sheep retrovirus, which may provide insight into human lung cancer.		miller/index.html
Moens Lab	Basic Sciences	The Moens Lab uses zebrafish as a model system to study how genes control the early development of the brain in vertebrates. Their work adds to our understanding of the causes of cancer because many of the genes that control embryonic development are the same ones that are wrongly regulated in cancer cells.		moens/index.html
Mueller Lab	Public Health Sciences	Dr. Mueller's research focuses on the roles of maternal, gestational, early life factors, and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. She also studies reproductive history in relation to cancer and cancer survival in women, and reproductive outcomes among male and female childhood cancer survivors.		mueller/index.html
Neiman Lab	Basic Sciences			neiman/index.html
Nelson Lab	Clinical Research	The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.		lnelson/index.html
Olson Lab	Clinical Research	The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.		olson/index.html
Paddison Lab	Human Biology			paddison/index.html
Pagel Lab	Clinical Research	The Pagel lab focuses on the development and improvement of antibody therapies for leukemia and lymphoma, with the goal of decreasing toxic side effects while increasing the treatment's effectiveness. Our projects focus on advancing radioimmunotherapy through a pre-targeted method of delivering radiation to tumor sites.		pagel/index.html
Parkhurst Lab	Basic Sciences	The Parkhurst Lab studies how genes get turned on and off as fruit-fly embryos develop and how errors in this process can lead to cancer and other diseases. They also investigate wound healing and complex signals involving proteins that can affect a cell's "skeletal" structure.	Parkhurst, Drosophila, Development, Genetics, Transcription, Repression, Segmentation, Fruit flies, Hutch, Fred Hutchinson, Basic science, Cytoskeleton, Morphogenesis, Signaling, Hairy, CtBP, Wimp, Rho GTPase, model organism, fruit fly, flies, Sir2, Groucho, Cappuccino, Embryo, Oogenesis, Morphology, Pair rule	parkhurst/index.html
Paulovich Lab	Clinical Research	The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.		paulovich/index.html
Peichel Lab	Human Biology	The Peichel Lab uses a small fish called the threespine stickleback as a model organism to conduct research aimed at identifying the genetic and molecular mechanisms that underlie evolutionary processes. Research topics include understanding evolution of the fish's behavior and sex chromosomes.		peichel/index.html
Pepe Lab	Public Health Sciences	The Pepe Lab develops guidelines and software to promote the use of sound statistical methods by scientists who are working to evaluate diagnostic or prognostic medical devices and biomarkers.		pepe/index.html
Peter Nelson Lab	Human Biology	Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.		pnelson/index.html
Porter Lab	Human Biology	The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.		porter/index.html
Press Lab	Clinical Research	Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.		press/index.html
Priess Lab	Basic Sciences	The Priess lab studies how cells coordinate their shape and fate during the development of complex tissues and organs. Most of these studies use the nematode C. elegans as a model organism.		priess/index.html
Radich Lab	Clinical Research	The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.		radich/index.html
Ramsey Lab	Public Health Sciences	Dr. Ramsey directs the Research and Economic Assessment in Cancer and Healthcare (REACH) group, which focuses on cutting-edge cost-effectiveness and outcomes research in cancer prevention and treatment. REACH also has experience in designing and performing cost-effectiveness analyses of drugs, devices and interventions, with an eye towards supporting public and private decision making to maximize health value under resource constraints.		ramsey/index.html
Research Cell Bank	Clinical Research	The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.	Lab, Contract, Fee for service, processing, Research, Cell, Bank, cell and gene bank, gene bank, Culture, DNA, HLA, HST, Transplant, Genomic, IHWG, international histocompatibility workshop, cell bank, biorepository, research cell bank, dna bank, service	research_cell_bank/index.html
Roberts Lab	Basic Sciences	The Roberts Lab has discovered key proteins that regulate cell division and explored how changes in cell-cycle proteins may inform the treatment of specific cancers. Current research focuses on the development of mouse models of human cancers.		roberts/index.html
Roth Lab	Basic Sciences	The Roth Lab studies suspended animation and metabolic hibernation as a means to temporarily halt, or "dial down," metabolism. One day such techniques may help to buy time for critically ill patients on organ-transplant lists and in trauma situations.		roth/index.html
Shimamura Lab	Clinical Research	The Shimamura Lab works to understand the molecular mechanisms contributing to development of blood cells (hematopoiesis) and cancer (tumorigenesis), with the ultimate goal of informing rationally designed therapeutic strategies. Their research focuses particularly on genetic marrow failure syndromes.		shimamura/index.html
Shou Lab	Basic Sciences	The Shou Lab uses experimental biology, mathematics and engineering to study a variety of biological problems. Research interests include how cooperative systems evolve despite threats from "cheaters" that consume benefits without paying a fair cost, and how cells cope with nutrient limitations.	shou lab, wenying shou, fred hutchinson cancer research center, fhcrc, quantitative biology group	shou/index.html
Simon Lab	Clinical Research	The Simon Lab works toward identifying new anticancer drugs through a wide range of experimental techniques and systems, ranging from organic synthesis to genetic screens.		simon/index.html
Smith Lab	Basic Sciences	The Smith Lab works to understand how genetic recombination and DNA repair are accomplished, and how they are regulated to occur at the proper place and time. As deviations in this process can result in birth defects and cancers, this work may lend insight into the causes of these diseases and ways of predicting or preventing them.	Smith, Hutch, Fred Hutchinson, Basic science, Genetics, S. cerevisiae, S. pombe, Biochemistry, DNA Repair, Genetic Diseases, Genetic Manipulation, Genetics, Genomics, Microbiology, Molecular Biology, Pathology, Recombinant DNA.Schizosaccharomyces Pombe	gsmith/index.html
Spies Lab	Clinical Research	The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.	Thomas Spies, Ph.D., immunology research at the Fred Hutchinson Cancer Research Center, NKG2D receptor, MICA ligand, tumor immunity, autoimmune disease	spies/index.html
Stoddard Lab	Basic Sciences	The Stoddard Lab studies the structure and mechanism of enzymes, the body's catalysts of biological reactions, in order to harness them for use in biotechnology and medicine. The engineering and redesign of certain enzymes could be used in targeted therapies for genetic diseases such as hemophilia and cystic fibrosis.		stoddard/index.html
Strong Lab	Basic Sciences	The Strong Lab analyzes the structure of proteins and protein-receptor complexes that control the immune system's response to disease. Building on the principles learned from these studies, they also participate in a collaborative project to design proteins for a vaccine to prevent AIDS.		strong/index.html
Tang Lab	Public Health Sciences			tang/index.html
Tapscott Lab	Human Biology	The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.		tapscott/index.html
Thompson Studies	Public Health Sciences	Led by Dr. Beti Thompson, this research group works to understand why disparities in cancer incidence and survival rates exist among different populations, especially Latinos. The group also supports efforts to reduce other health disparities, including diabetes and pesticide exposure, in minority communities in the United States and abroad.		thompson/index.html
Trask Lab	Human Biology	The Trask Lab investigates the organization of the human genome to understand recent evolutionary change, assess normal genetic variation, and detect genetic abnormalities that contribute to cancer and other diseases.		trask/index.html
Tsukiyama Lab	Basic Sciences	The Tsukiyama Lab studies chromatin, the complex of DNA and proteins that make up our chromosomes, and how chromatin structure controls essential processes that take place on DNA.	Tsukiyama, Biochemistry, DNA Repair, DNA Replication, Transcription, Chromatin, SWI, S. cerevisiae, nucleosome, in vitro	tsukiyama/index.html
Ulrich Lab	Public Health Sciences		Neli Ulrich	ulrich/index.html
Van Gilst Lab	Basic Sciences	The Van Gilst Lab investigates the mechanics of two fundamentally distinct metabolic states in animals--those adopted while feeding and while fasting--and works to understand how those programs relate to key aspects of physiology, disease and aging.	C. elegans, Fatty Acid, nutrition, fasting, feeding, Marc Van Gilst, stable isotope, GC/MS	vangilst/index.html
Vasioukhin Lab	Human Biology	The Vasioukhin Lab works to better understand how individual cells work together to produce and maintain a normal mammalian organism. The underlying idea is that cancer can occur as a result of breakdowns in the mechanisms that regulate this communication.		vasioukhin/index.html
Warren Lab	Clinical Research	The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.		warren/index.html

Lab Name

Division

Description

Keywords

Lab URL

Bedalov Lab

Clinical Research

The Bedalov Lab conducts research to identify drugs that disrupt gene silencing, a process that has been implicated in cancer and other diseases in which genes are inappropriately shut off.

bedalov/index.html

Bielas Lab

Public Health Sciences

The Bielas Lab studies the fundamental and clinical implications of nuclear and mitochondrial DNA mutations in the development of cancer and age-related disease. Translational research projects explore the potential utility of these mutations as novel DNA biomarkers for improved disease detection, treatment outcome, survival and quality of life.

bielas/index.html

Biggins Lab

Basic Sciences

The Biggins Lab uses budding yeast to study chromosome segregation, the process by which chromosomes are distributed to new cells during cell division. Cells with an abnormal number of chromosomes are a hallmark of cancer and many birth defects.

Biggins, Yeast, Cell cycle, Genetics, Cell biology, Ipl1/aurora protein kinase, CenH3 histone variant, Hutch, Fred Hutchinson, Basic sciences, Cytoskeleton, microtubules, kinetochores

biggins/index.html

Breeden Lab

Basic Sciences

The Breeden Lab investigates control of cell division in budding yeast, with a long-term goal of understanding how the commitment to the mitotic cell cycle is regulated in response to environmental and internal cues.

breeden/index.html

Brent Lab

Basic Sciences

The Brent Lab studies how living cells sense, represent, transmit and act upon information to make decisions about their future states. The lab includes, experimentally, a social science component, in which lab members are encouraged to identify and analyze how their research outcomes and ongoing increases in biological knowledge might impact human affairs.

brent/index.html

Chen Lab

Public Health Sciences

The Chu Chen Lab is conducting a hospital-based study to discover biomarkers that may improve diagnosis and prognosis of oral cancer. Several other studies focus on the links between genetic and environmental factors and development of, and/or survival from, tobacco-related and hormone-related cancers.

chen/index.html

Clurman Lab

Clinical Research

The Clurman Lab studies how cell division is regulated in normal cells, and how abnormal control of cell division leads to cancer. They hope to use these mechanistic insights into tumor formation to develop new cancer treatment strategies.

clurman/index.html

Cooper Lab

Basic Sciences

The Cooper Lab investigates proteins involved in the signaling pathways that allow cells to communicate with each other. In particular, they study a protein called Disabled and the Src protein family to better understand how they regulate normal cell behavior and the transformation of normal cells to cancer cells.

Cooper, Yeast, Cell cycle, Genetics, Cell biology, Ipl1/aurora protein kinase, CenH3 histone variant, Hutch, Fred Hutchinson, Basic sciences, Cytoskeleton, microtubules, kinetochores

cooper/index.html

Eisenman Lab

Basic Sciences

The Eisenman Lab studies how cell proliferation, growth, and differentiation are regulated through the actions of transcriptional networks, and how this regulation is undermined during tumor progression. The lab employs the tools of molecular biology as well as mammalian and Drosophila genetics to study basic mechanisms underlying normal and abnormal cellular functions.

eisenman/index.html

Emerman Lab

Human Biology

The Emerman Lab studies the molecular and evolutionary basis for the replication of HIV and related viruses, with an emphasis on the interaction of these viruses with their host cells. Their goal is to understand what determines resistance or vulnerability to current, past and potential viral diseases.

emerman/index.html

Etzioni Lab

Public Health Sciences

The Etzioni Lab focuses on statistical methods for prostate-cancer studies, with the goal of improving guidelines for screening and treatment. Etzioni has assessed the likely impact of prostate-specific antigen testing on prostate-cancer incidence and mortality, and developed approaches for evaluating new cancer-screening biomarkers.

etzioni/index.html

Fero Lab

Clinical Research

The Fero Lab studies how cell-cycle regulatory genes, p27 and Rb, control growth of tumors and normal tissues. Using novel mouse models and genomic technologies, they have discovered that cell cycle inhibitors and microRNAs regulate T-cell growth and differentiation, whereas mutations of these genes cooperate in lymphoma development.

fero/index.html

Ferré-D'Amaré

Basic Sciences

The Ferré-D'Amaré Lab studies the structural underpinnings of RNA's biological functions using biochemistry, X-ray crystallography, and other biophysical techniques. Because RNA plays critical roles in the cell, both in health and disease, an atomic-level understanding of its function provides the basis for development of new therapies.

ferre/index.html

Galloway Lab

Human Biology

The Galloway Lab studies the mechanisms by which human papillomaviruses contribute to cancer, with an emphasis on types most likely to progress to cervical cancer. They work to understand the natural history of genital HPV infections and why only a small subset of women infected with high-risk HPVs develop cancer.

galloway/index.html

Geballe Lab

Human Biology

The Geballe Lab studies the functions and mechanisms of genes encoded by large DNA viruses, such as cytomegalovirus and vaccinia virus, that act to promote viral growth by blocking host cell defenses.

geballe/index.html

Gottschling Lab

Basic Sciences

The Gottschling Lab uses budding yeast as a model system to investigate fundamental questions in biology. One of their current areas of research interest is the striking link between increasing age and cancer incidence in humans.

gottschling/index.html

Greenberg Lab

Clinical Research

The Greenberg Lab's guiding research goals are to understand the principles underlying T cell recognition of viruses and cancer cells, to determine why such responses often fail to eliminate the virus or cancer, and to develop cellular and molecular approaches that manipulate the immune system to treat human viral and malignant diseases.

pgreenberg/index.html

Hahn Lab

Basic Sciences

The Hahn Lab studies the mechanism and regulation of transcription, the process of mRNA synthesis. Transcriptional regulation is one of the key steps controlling cell growth, differentiation and development, and defects cause many human illnesses. Using biochemistry, structural biology and molecular genetics, the lab focuses on the mechanism of the large conserved protein complexes that regulate and promote transcription.

polymerase II, polymerase III, RNA polymerase, TATA binding protein, TBP, TFIID, TFIIA, TFIIB, gene regulation, holoenzyme, biochemistry, genetics, structure, yeast, protein, DNA, mechanism, BRF, TFIIIC, TFIIIB, Zn-ribbon, Steven Hahn, Seattle, Fred Hutchinson, Howard Hughes, cancer, molecular, biology, saccharomyces cerevisiae, graduate study, Washington

hahn/index.html

Hanash Lab

Public Health Sciences

The Hanash Lab works to discover trace proteins called "markers" that are released into the blood by diseased tissues. The goal of this research is to develop more effective tests for early detection and diagnosis of lung, breast, colon, ovarian and pancreatic cancers as well as other common diseases.

hanash/index.html

Hansen Lab

Clinical Research

Hansen, John Hansen, Research Cell Bank, HIP, Transplant, GVHD

hansen/index.html

Heimfeld Lab

Clinical Research

The Heimfeld Lab focuses on the translation of new cell-based therapies from the scientist's bench to the patient's bedside. Areas of research include improvements in specific cell-subset selection, large-scale therapeutic-cell culturing in closed systems, optimized cryopreservation and cell storage.

heimfeld/index.html

Henikoff Lab

Basic Sciences

The Henikoff Lab studies the structure, function and evolution of chromosomes. They also develop tools for epigenomics and functional genomics.

henikoff/index.html

Hockenbery Lab

Clinical Research

The Hockenbery lab studies programmed cell death (apoptosis) pathways that are defective in many cancer cells; and the role of cancer-cell metabolism in apoptosis, oncogene functions, and environmental/dietary risk factors, including excess supply of nutrients. After identifying cancer-selective targets, they carry out small-molecule screens for inhibitors to identify lead compounds as anticancer agents.

hockenbery/index.html

Kemp Lab

Human Biology

The Kemp Lab studies tumor formation in mice to better understand how environmental and genetic factors interact to cause cancer. They also work to develop simple blood tests for early cancer detection by discovering biomarkers, the proteins that signal the earliest traces of disease.

kemp/index.html

Kiem Lab

Clinical Research

The Kiem Lab studies stem cell biology and stem cell gene transfer with the goal of developing new treatment strategies for patients with genetic and infectious diseases and cancers.

kiem/index.html

Knudsen Lab

Public Health Sciences

The Knudsen Lab works to discover new biomarkers related to preventing, treating and predicting the course of prostate cancer. Other projects include understanding why this cancer spreads and assessing the effects of sulforaphane, an active ingredient in cruciferous vegetables, on prostate-cancer prevention.

knudsen/index.html

Lampe Lab

Public Health Sciences

The Paul Lampe Lab attempts to discover early detection cancer biomarkers and investigates the control of cell growth at the cell biology level. Of particular interest is the role that gap junctions play in the regulation of cell growth and the cell cycle, and the disruption of this relationship during cancer development.

lampe/index.html

Li Lab

Public Health Sciences

Dr. Li uses a multidisciplinary approach to understand factors related to the causes and patient outcomes of breast cancer. Current projects include identifying new biomarkers that could be used for early detection, evaluating risk factors for different types of breast cancer, determining predictors of poor outcomes among breast cancer survivors, and assessing disparities in cancer stage, treatment and survival by race/ethnicity.

li/index.html

Madeleine Lab

Public Health Sciences

Dr. Madeleine's research focuses primarily on the molecular epidemiology of disease-causing agents, or pathogens, and the immune response to them that may be associated with cancer development and prognosis. Another interest is the role of chronic, undiagnosed immune system dysfunctions (such as those occurring with age, obesity, physical inactivity, hormone use, and UV exposure) in cancer development.

madeleine/index.html

Malik Lab

Basic Sciences

The Malik Lab hunts for rapidly evolving proteins in order to understand how conflicts between genes affect human evolution. Such genetic conflicts can arise between virus and host genes as each fights for survival, but they can affect the function of essential genes, including those implicated in cancer.

Malik, Hutch, Fred Hutchinson, Basic science, Biochemistry, Proteins, Bioinformatics, Biological Sciences, Cell Cycle, Chemical Engineering, Evolution, Genetics, Genomics, Molecular Biology, Phylogenetics, Plasmids, Retrovirus, 2 Micron Plasmid, Bioinformatics, Centromeres, Chromatin, Genomics, Mobile Genetic Elements, Molecular Evolution, Rapidly Evolving Proteins

malik/index.html

McElrath Lab

Clinical Research

The McElrath Lab is dedicated to understanding the human immune response mechanisms in HIV infection and resistance in a way that can be translated into the development of an effective HIV vaccine.

mcelrath/index.html

McGregor Lab

Public Health Sciences

The McGregor Lab leads the Stress Management and Relaxation Training, or SMART, studies, which focus on understanding the effects of stress management on behavioral and biological factors that are relevant to cancer development, such as diet, exercise, immune function, DNA repair and cellular aging processes.

mcgregor/index.html

McIntosh Lab

Public Health Sciences

The McIntosh Lab develops primarily computational approaches for studying proteins and genomes in cancer. Their primary goal is to discover and evaluate diagnostic and early-detection biomarkers in serum, with research projects in ovarian, breast and pancreatic cancer and neurodegenerative diseases.

mcintosh/index.html

Miller Lab

Human Biology

The Miller Lab studies the basic biology of viral gene transfer. Their goals include developing gene-therapy treatments for lung diseases and generating induced pluripotent stem cells, which are useful for cell therapy in humans. Another major focus has been the jaagsiekte sheep retrovirus, which may provide insight into human lung cancer.

miller/index.html

Moens Lab

Basic Sciences

The Moens Lab uses zebrafish as a model system to study how genes control the early development of the brain in vertebrates. Their work adds to our understanding of the causes of cancer because many of the genes that control embryonic development are the same ones that are wrongly regulated in cancer cells.

moens/index.html

Mueller Lab

Public Health Sciences

Dr. Mueller's research focuses on the roles of maternal, gestational, early life factors, and early environmental exposures in the occurrence of childhood cancer and autoimmune diseases. She also studies reproductive history in relation to cancer and cancer survival in women, and reproductive outcomes among male and female childhood cancer survivors.

mueller/index.html

Neiman Lab

Basic Sciences

neiman/index.html

Nelson Lab

Clinical Research

The J. Lee Nelson Lab studies microchimerism, a natural state in which cells are exchanged between mother and fetus during pregnancy and can remain in the other individual decades later. They study the role of this phenomenon in autoimmune diseases, pregnancy complications and cancer, as well as its impact on the success of blood stem-cell and organ transplants.

lnelson/index.html

Olson Lab

Clinical Research

The Olson Lab studies pediatric brain tumors, brain development and neurodegenerative disorders. The lab has a strong focus on emergent technologies such as "tumor paint," which causes cancer cells to glow with light so that surgeons can see them during an operation.

olson/index.html

Paddison Lab

Human Biology

paddison/index.html

Pagel Lab

Clinical Research

The Pagel lab focuses on the development and improvement of antibody therapies for leukemia and lymphoma, with the goal of decreasing toxic side effects while increasing the treatment's effectiveness. Our projects focus on advancing radioimmunotherapy through a pre-targeted method of delivering radiation to tumor sites.

pagel/index.html

Parkhurst Lab

Basic Sciences

The Parkhurst Lab studies how genes get turned on and off as fruit-fly embryos develop and how errors in this process can lead to cancer and other diseases. They also investigate wound healing and complex signals involving proteins that can affect a cell's "skeletal" structure.

Parkhurst, Drosophila, Development, Genetics, Transcription, Repression, Segmentation, Fruit flies, Hutch, Fred Hutchinson, Basic science, Cytoskeleton, Morphogenesis, Signaling, Hairy, CtBP, Wimp, Rho GTPase, model organism, fruit fly, flies, Sir2, Groucho, Cappuccino, Embryo, Oogenesis, Morphology, Pair rule

parkhurst/index.html

Paulovich Lab

Clinical Research

The Paulovich Lab works to characterize human variation and to relate this variation to clinically relevant endpoints, such as predicting a patient's risk of cancer and tolerance for treatments. Projects range from studying cellular DNA damage response in yeast and mammalian cells, to developing novel mass spectrometry-based technologies for finding and validating new protein biomarkers to serve as diagnostic tests.

paulovich/index.html

Peichel Lab

Human Biology

The Peichel Lab uses a small fish called the threespine stickleback as a model organism to conduct research aimed at identifying the genetic and molecular mechanisms that underlie evolutionary processes. Research topics include understanding evolution of the fish's behavior and sex chromosomes.

peichel/index.html

Pepe Lab

Public Health Sciences

The Pepe Lab develops guidelines and software to promote the use of sound statistical methods by scientists who are working to evaluate diagnostic or prognostic medical devices and biomarkers.

pepe/index.html

Peter Nelson Lab

Human Biology

Dr. Peter Nelson's lab focuses on understanding the molecular, cellular and physiological events that lead to cancer initiation and progression. A particular emphasis involves hormonal carcinogenesis and prostate cancer with the goal of developing new strategies for diagnosis, prognosis and therapy.

pnelson/index.html

Porter Lab

Human Biology

The Porter Lab focuses on identifying and understanding the molecular events in normal and cancer cells that are associated with the initiation and progression of human cancer, with a focus on breast and ano-genital cancers. They also investigate the molecular profiles that distinguish different types of cancer or determine an individual's cancer risk.

porter/index.html

Press Lab

Clinical Research

Dr. Press is a pioneer in immunotherapy, a treatment strategy that harnesses the power of the immune system. His lab engineers antibodies that help to destroy cells involved in blood cancers and carry radiation directly to cancer cells. They also genetically modify disease-fighting T-cells to boost their ability to recognize and kill lymphoma cells.

press/index.html

Priess Lab

Basic Sciences

The Priess lab studies how cells coordinate their shape and fate during the development of complex tissues and organs. Most of these studies use the nematode C. elegans as a model organism.

priess/index.html

Radich Lab

Clinical Research

The Radich Lab studies the molecular genetics of response, progression and relapse in human leukemia. Research topics include the detection of minimal residual disease, the role of signal transduction abnormalities in leukemia, and the construction of gene-expression profiles of response and progression.

radich/index.html

Ramsey Lab

Public Health Sciences

Dr. Ramsey directs the Research and Economic Assessment in Cancer and Healthcare (REACH) group, which focuses on cutting-edge cost-effectiveness and outcomes research in cancer prevention and treatment. REACH also has experience in designing and performing cost-effectiveness analyses of drugs, devices and interventions, with an eye towards supporting public and private decision making to maximize health value under resource constraints.

ramsey/index.html

Research Cell Bank

Clinical Research

The Research Cell Bank (RCB) is a qualified, experienced research facility that has been actively engaged in clinical research through B-lymphoblastoid cell (B-LCL) transformation and maintenance, DNA extraction, and inventory control for more than 30 years. The RCB is currently expanding its role as a core repository of reagents and services to better serve the needs of investigators worldwide.

Lab, Contract, Fee for service, processing, Research, Cell, Bank, cell and gene bank, gene bank, Culture, DNA, HLA, HST, Transplant, Genomic, IHWG, international histocompatibility workshop, cell bank, biorepository, research cell bank, dna bank, service

research_cell_bank/index.html

Roberts Lab

Basic Sciences

The Roberts Lab has discovered key proteins that regulate cell division and explored how changes in cell-cycle proteins may inform the treatment of specific cancers. Current research focuses on the development of mouse models of human cancers.

roberts/index.html

Roth Lab

Basic Sciences

The Roth Lab studies suspended animation and metabolic hibernation as a means to temporarily halt, or "dial down," metabolism. One day such techniques may help to buy time for critically ill patients on organ-transplant lists and in trauma situations.

roth/index.html

Shimamura Lab

Clinical Research

The Shimamura Lab works to understand the molecular mechanisms contributing to development of blood cells (hematopoiesis) and cancer (tumorigenesis), with the ultimate goal of informing rationally designed therapeutic strategies. Their research focuses particularly on genetic marrow failure syndromes.

shimamura/index.html

Shou Lab

Basic Sciences

The Shou Lab uses experimental biology, mathematics and engineering to study a variety of biological problems. Research interests include how cooperative systems evolve despite threats from "cheaters" that consume benefits without paying a fair cost, and how cells cope with nutrient limitations.

shou lab, wenying shou, fred hutchinson cancer research center, fhcrc, quantitative biology group

shou/index.html

Simon Lab

Clinical Research

The Simon Lab works toward identifying new anticancer drugs through a wide range of experimental techniques and systems, ranging from organic synthesis to genetic screens.

simon/index.html

Smith Lab

Basic Sciences

The Smith Lab works to understand how genetic recombination and DNA repair are accomplished, and how they are regulated to occur at the proper place and time. As deviations in this process can result in birth defects and cancers, this work may lend insight into the causes of these diseases and ways of predicting or preventing them.

Smith, Hutch, Fred Hutchinson, Basic science, Genetics, S. cerevisiae, S. pombe, Biochemistry, DNA Repair, Genetic Diseases, Genetic Manipulation, Genetics, Genomics, Microbiology, Molecular Biology, Pathology, Recombinant DNA.Schizosaccharomyces Pombe

gsmith/index.html

Spies Lab

Clinical Research

The Spies Lab focuses on experimental studies of the human NKG2D lymphocyte receptor and its ligands, and the mechanisms whereby these proteins stimulate or suppress immune responses against cancer and in autoimmune disease.

Thomas Spies, Ph.D., immunology research at the Fred Hutchinson Cancer Research Center, NKG2D receptor, MICA ligand, tumor immunity, autoimmune disease

spies/index.html

Stoddard Lab

Basic Sciences

The Stoddard Lab studies the structure and mechanism of enzymes, the body's catalysts of biological reactions, in order to harness them for use in biotechnology and medicine. The engineering and redesign of certain enzymes could be used in targeted therapies for genetic diseases such as hemophilia and cystic fibrosis.

stoddard/index.html

Strong Lab

Basic Sciences

The Strong Lab analyzes the structure of proteins and protein-receptor complexes that control the immune system's response to disease. Building on the principles learned from these studies, they also participate in a collaborative project to design proteins for a vaccine to prevent AIDS.

strong/index.html

Tang Lab

Public Health Sciences

tang/index.html

Tapscott Lab

Human Biology

The Tapscott Lab studies gene transcription and expression in normal development and disease, with an additional emphasis on rhabdomysarcomas (cancers with characteristics of skeletal muscle) and human muscular dystrophies. Other research areas include gene and cell therapies for muscular dystrophy, and the biology of triplet repeats and their associated diseases.

tapscott/index.html

Thompson Studies

Public Health Sciences

Led by Dr. Beti Thompson, this research group works to understand why disparities in cancer incidence and survival rates exist among different populations, especially Latinos. The group also supports efforts to reduce other health disparities, including diabetes and pesticide exposure, in minority communities in the United States and abroad.

thompson/index.html

Trask Lab

Human Biology

The Trask Lab investigates the organization of the human genome to understand recent evolutionary change, assess normal genetic variation, and detect genetic abnormalities that contribute to cancer and other diseases.

trask/index.html

Tsukiyama Lab

Basic Sciences

The Tsukiyama Lab studies chromatin, the complex of DNA and proteins that make up our chromosomes, and how chromatin structure controls essential processes that take place on DNA.

Tsukiyama, Biochemistry, DNA Repair, DNA Replication, Transcription, Chromatin, SWI, S. cerevisiae, nucleosome, in vitro

tsukiyama/index.html

Ulrich Lab

Public Health Sciences

Neli Ulrich

ulrich/index.html

Van Gilst Lab

Basic Sciences

The Van Gilst Lab investigates the mechanics of two fundamentally distinct metabolic states in animals--those adopted while feeding and while fasting--and works to understand how those programs relate to key aspects of physiology, disease and aging.

C. elegans, Fatty Acid, nutrition, fasting, feeding, Marc Van Gilst, stable isotope, GC/MS

vangilst/index.html

Vasioukhin Lab

Human Biology

The Vasioukhin Lab works to better understand how individual cells work together to produce and maintain a normal mammalian organism. The underlying idea is that cancer can occur as a result of breakdowns in the mechanisms that regulate this communication.

vasioukhin/index.html

Warren Lab

Clinical Research

The Warren Lab studies human antitumor immune responses at the cellular and molecular level in order to learn how these immune responses can be exploited to treat human cancer.

warren/index.html

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